Articles with "scaffolds design" as a keyword



Benzoisoxazoles as Privileged Scaffolds in Design and Synthesis of N‐Containing Molecules: Recent Update

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Published in 2024 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202401021

Abstract: Benzoisoxazoles, with a distinctive 10‐π‐electron system and significant polarity, readily trigger N‐O bond cleavage, enabling multifaceted applications in organic synthesis. Over the past decade, the exponentially increased use of benzoisoxazoles towards the synthesis of highly valuable N‐containing scaffolds, especially… read more here.

Keywords: privileged scaffolds; scaffolds design; benzoisoxazoles privileged; synthesis ... See more keywords

Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors

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Published in 2022 at "Expert Opinion on Drug Discovery"

DOI: 10.1080/17460441.2022.2043845

Abstract: ABSTRACT Introduction The different and relevant roles of GSK-3 are of critical importance since they deal with development, metabolic homeostasis, cell polarity and fate, neuronal growth and differentiation as well as modulation of apoptotic potential.… read more here.

Keywords: products novel; kinase inhibitors; natural products; scaffolds design ... See more keywords