Modular Synthesis of Polar Spirocyclic Scaffolds Enabled by Radical Chemistry.
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DOI: 10.1021/acs.orglett.3c00869
Abstract: Herein, we report a highly modular strategy to access spirocyclic scaffolds from abundant starting materials, i.e., cyclic ketones and α-amino or oxamic acids. The sequence proceeds through a straightforward Knoevenagel condensation, followed by a domino… read more here.
Keywords: spirocyclic scaffolds; chemistry; polar spirocyclic; scaffolds enabled ... See more keywords