A Robust and Scalable Process for the Synthesis of Substantially Pure Clarithromycin 9-(E)-Oxime with an Established Control of the (Z)-Isomer Impurity
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c08207
Abstract: Controlling the isomeric impurity in a key raw material is always critical to achieve the corresponding pure isomer-free targeted active pharmaceutical ingredient (API) in downstream processing. Clarithromycin 9-(E)-oxime is the key raw material for the… read more here.
Keywords: clarithromycin; scalable process; clarithromycin oxime; synthesis ... See more keywords
An efficient and scalable process to produce morpholine-d8
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DOI: 10.1080/00397911.2016.1266502
Abstract: ABSTRACT Incorporation of isotopes has long been used as a research tool to label carbons and elucidate biochemical pathways. More recently, H→D exchange has led to analogs of therapeutic agents with improved metabolic stability and… read more here.
Keywords: produce morpholine; scalable process; efficient scalable; process ... See more keywords
Development of a Scalable Process of Film-Coated bi-Layer Tablet Containing Sustained-Release Metoprolol Succinate and Immediate-Release Amlodipine Besylate
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DOI: 10.3390/pharmaceutics13111797
Abstract: The development of new drugs that combine active ingredients for the treatment hypertension is critically essential owing to its offering advantages for both patients and manufacturers. In this study, for the first time, detailed development… read more here.
Keywords: scalable process; process; film coated; metoprolol succinate ... See more keywords