Scalable Total Synthesis of (-)-Triptonide: Serendipitous Discovery of a Visible-Light-Promoted Olefin Coupling Initiated by Metal-Catalyzed Hydrogen Atom Transfer (MHAT).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12525
Abstract: An efficient and scalable total synthesis of (-)-triptonide is accomplished based on a metal-catalyzed hydrogen atom transfer (MHAT)-initiated radical cyclization. During the optimization of the key step, we discovered that blue LEDs significantly promoted the… read more here.
Keywords: synthesis triptonide; hydrogen atom; scalable total; catalyzed hydrogen ... See more keywords
Scalable total synthesis of a mycobactin T analogue utilizing a novel synthetic and protection strategy
Sign Up to like & getrecommendations! Published in 2019 at "Organic Chemistry Frontiers"
DOI: 10.1039/c9qo00502a
Abstract: Mycobactin T analogue 1 (MbT-1) is a mycobacterial-specific siderophore analogue, which is usually employed to conjugate therapeutic drugs to induce selective antibacterial activity. read more here.
Keywords: scalable total; mycobactin analogue; analogue; total synthesis ... See more keywords