Large-Scale Ligand Perturbations of the Protein Conformational Landscape Reveal State-Specific Interaction Hotspots
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DOI: 10.1021/acs.jmedchem.2c00708
Abstract: Protein flexibility is important for ligand binding but often ignored in drug design. Considering proteins as ensembles rather than static snapshots creates opportunities to target dynamic proteins that lack FDA-approved drugs, such as the human… read more here.
Keywords: scale ligand; large scale; ligand; conformational landscape ... See more keywords