Efficient gene–environment interaction tests for large biobank‐scale sequencing studies
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DOI: 10.1002/gepi.22351
Abstract: Complex human diseases are affected by genetic and environmental risk factors and their interactions. Gene–environment interaction (GEI) tests for aggregate genetic variant sets have been developed in recent years. However, existing statistical methods become rate… read more here.
Keywords: scale sequencing; sequencing studies; gene environment; environment interaction ... See more keywords
Dating genomic variants and shared ancestry in population-scale sequencing data
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DOI: 10.1371/journal.pbio.3000586
Abstract: The origin and fate of new mutations within species is the fundamental process underlying evolution. However, while much attention has been focused on characterizing the presence, frequency, and phenotypic impact of genetic variation, the evolutionary… read more here.
Keywords: genomic variants; sequencing data; age; variants shared ... See more keywords
Large-Scale Sequencing of Borreliaceae for the Construction of Pan-Genomic-Based Diagnostics
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DOI: 10.3390/genes13091604
Abstract: The acceleration of climate change has been associated with an alarming increase in the prevalence and geographic range of tick-borne diseases (TBD), many of which have severe and long-lasting effects—particularly when treatment is delayed principally… read more here.
Keywords: scale sequencing; sequencing borreliaceae; large scale; construction pan ... See more keywords