A genome-wide scan statistic framework for whole-genome sequence data analysis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11023-0
Abstract: The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose… read more here.
Keywords: genome wide; statistic framework; whole genome; scan statistic ... See more keywords
Using the maximum clustering heterogeneous set-proportion to select the maximum window size for the spatial scan statistic
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61829-y
Abstract: The spatial scan statistic has been widely used to detect spatial clusters that are of common interest in many health-related problems. However, in most situations, different scan parameters, especially the maximum window size (MWS), result… read more here.
Keywords: maximum clustering; spatial scan; scan statistic; set proportion ... See more keywords
Sequential Data-Mining for Adverse Events after Recombinant Herpes Zoster Vaccination Using the Tree-Based Scan Statistic.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of epidemiology"
DOI: 10.1093/aje/kwac176
Abstract: Tree-based scan statistics have been successfully used to study the safety of several vaccines without prespecifying health outcomes of concern. In this study, the binomial tree-based scan statistic was applied sequentially to detect adverse events… read more here.
Keywords: tree based; recombinant herpes; vaccination; based scan ... See more keywords
Detecting the spatial clustering of exposure-response relationships with estimation error: a novel spatial scan statistic.
Sign Up to like & getrecommendations! Published in 2023 at "Biometrics"
DOI: 10.1111/biom.13861
Abstract: Detecting the spatial clustering of the exposure-response relationship (ERR) between environmental risk factors and health-related outcomes plays important roles in disease control and prevention, such as identifying highly sensitive regions, exploring the causes of heterogeneous… read more here.
Keywords: estimation error; scan statistic; spatial scan; spatial clustering ... See more keywords
Quantitative phenotype scan statistic (QPSS) reveals rare variant associations with Alzheimer’s disease endophenotypes
Sign Up to like & getrecommendations! Published in 2020 at "BMC Medical Genetics"
DOI: 10.1186/s12881-020-01046-6
Abstract: Background Current sequencing technologies have provided for a more comprehensive genome-wide assessment and have increased genotyping accuracy of rare variants. Scan statistic approaches have previously been adapted to genetic sequencing data. Unlike currently-employed association tests,… read more here.
Keywords: scan statistic; phenotype scan; alzheimer disease; quantitative phenotype ... See more keywords
A log-Weibull spatial scan statistic for time to event data
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Health Geographics"
DOI: 10.1186/s12942-018-0137-9
Abstract: BackgroundSpatial scan statistics have been used for the identification of geographic clusters of elevated numbers of cases of a condition such as disease outbreaks. These statistics accompanied by the appropriate distribution can also identify geographic… read more here.
Keywords: spatial scan; scan statistic; log weibull; time ... See more keywords