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Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11023-0
Abstract: The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose…
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Keywords:
genome wide;
statistic framework;
whole genome;
scan statistic ... See more keywords
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Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61829-y
Abstract: The spatial scan statistic has been widely used to detect spatial clusters that are of common interest in many health-related problems. However, in most situations, different scan parameters, especially the maximum window size (MWS), result…
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Keywords:
maximum clustering;
spatial scan;
scan statistic;
set proportion ... See more keywords
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Published in 2022 at "American journal of epidemiology"
DOI: 10.1093/aje/kwac176
Abstract: Tree-based scan statistics have been successfully used to study the safety of several vaccines without prespecifying health outcomes of concern. In this study, the binomial tree-based scan statistic was applied sequentially to detect adverse events…
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Keywords:
tree based;
recombinant herpes;
vaccination;
based scan ... See more keywords
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Published in 2023 at "Biometrics"
DOI: 10.1111/biom.13861
Abstract: Detecting the spatial clustering of the exposure-response relationship (ERR) between environmental risk factors and health-related outcomes plays important roles in disease control and prevention, such as identifying highly sensitive regions, exploring the causes of heterogeneous…
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Keywords:
estimation error;
scan statistic;
spatial scan;
spatial clustering ... See more keywords
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Published in 2020 at "BMC Medical Genetics"
DOI: 10.1186/s12881-020-01046-6
Abstract: Background Current sequencing technologies have provided for a more comprehensive genome-wide assessment and have increased genotyping accuracy of rare variants. Scan statistic approaches have previously been adapted to genetic sequencing data. Unlike currently-employed association tests,…
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Keywords:
scan statistic;
phenotype scan;
alzheimer disease;
quantitative phenotype ... See more keywords
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Published in 2018 at "International Journal of Health Geographics"
DOI: 10.1186/s12942-018-0137-9
Abstract: BackgroundSpatial scan statistics have been used for the identification of geographic clusters of elevated numbers of cases of a condition such as disease outbreaks. These statistics accompanied by the appropriate distribution can also identify geographic…
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Keywords:
spatial scan;
scan statistic;
log weibull;
time ... See more keywords