KDS2010, a reversible MAO‐B inhibitor, extends the lifetime of neural probes by preventing glial scar formation
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24500
Abstract: Implantable neural probes have been extensively utilized in the fields of neurocircuitry, systems neuroscience, and brain‐computer interface. However, the long‐term functionality of these devices is hampered by the formation of glial scar and astrogliosis at… read more here.
Keywords: formation; glial scar; scar formation; mao ... See more keywords
The Effect of MMP-1 on Wound Healing and Scar Formation
Sign Up to like & getrecommendations! Published in 2021 at "Aesthetic Plastic Surgery"
DOI: 10.1007/s00266-021-02369-2
Abstract: In this study, we investigated the effect of matrix metalloproteinase-1 (MMP-1) on wound healing on skin in a model produced in rats. Sixteen Sprague–Dawley male rats were included in the study. The four full-thickness skin… read more here.
Keywords: wound healing; group; mmp; formation ... See more keywords
Type 2 diabetes as a risk factor for promoting hypertrophic scar formation after wound healing: a two-sample mendelian randomization study
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-025-04101-5
Abstract: Individuals with type 2 diabetes mellitus (T2DM) not only face the risk of difficult wound healing after trauma or surgery but also struggle with scar formation after wound healing. However, the relationship between T2DM and… read more here.
Keywords: formation wound; type diabetes; wound healing; mendelian randomization ... See more keywords
The Role of Inflammatory Cascade and Reactive Astrogliosis in Glial Scar Formation Post-spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2024 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-024-01519-9
Abstract: Reactive astrogliosis and inflammation are pathologic hallmarks of spinal cord injury. After injury, dysfunction of glial cells (astrocytes) results in glial scar formation, which limits neuronal regeneration. The blood–spinal cord barrier maintains the structural and… read more here.
Keywords: cord; spinal cord; glial scar; injury ... See more keywords
Smad interacting protein 1 influences transforming growth factor-β1/Smad signaling in extracellular matrix protein production and hypertrophic scar formation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-019-09844-w
Abstract: The transforming growth factor (TGF)-β/Smad signal transduction pathway is closely associated with hypertrophic scar (HS) formation. Smad interacting protein 1 (SIP1) is a cytoplasmic protein that efficiently regulates Smad2-/3-dependent signaling within the TGF-β1 pathway. SIP1… read more here.
Keywords: protein; transforming growth; smad; scar formation ... See more keywords
Use of Lasers in Wound Healing: How to Best Utilize Laser Technology to Prevent Scar Formation
Sign Up to like & getrecommendations! Published in 2018 at "Current Dermatology Reports"
DOI: 10.1007/s13671-018-0240-y
Abstract: Purpose of ReviewThe purpose of this review is to evaluate the efficacy of early intervention in wound healing on scar formation across multiple scar types and progressions. The types of scars consist of hypertrophic, atrophic,… read more here.
Keywords: wound healing; treatment; laser; scar formation ... See more keywords
Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.03.161
Abstract: It is of great clinical significance to design wound dressing materials with combined excellent wound healing properties and superior capability to suppress hypertrophic scar formation. This study aimed to examine if and how the cationicity… read more here.
Keywords: wound healing; hypertrophic scar; chitosan; scar formation ... See more keywords
TGN‐020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.03.007
Abstract: Aims: Identifying drugs that inhibit edema and glial scar formation and increase neuronal survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2‐(nicotinamide)‐1,3,4‐thiadiazole (TGN‐020), a potent selective inhibitor of aquaporin… read more here.
Keywords: glial scar; spinal cord; scar formation; tgn 020 ... See more keywords
Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.
Sign Up to like & getrecommendations! Published in 2018 at "Ophthalmology"
DOI: 10.1016/j.ophtha.2018.01.004
Abstract: PURPOSE To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN Multicenter, prospective cohort study. PARTICIPANTS A total of… read more here.
Keywords: fibrotic scar; scar; scar formation; ahr versus ... See more keywords
Unraveling the landscape of m6A RNA methylation in wound healing and scars
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DOI: 10.1038/s41420-024-02222-w
Abstract: Wound healing is a complex process involving sequential stages of hemostasis, inflammation, proliferation, and remodeling. Multiple cell types and factors, including underlying conditions like diabetes and bacterial colonization, can influence healing outcomes and scar formation.… read more here.
Keywords: m6a; methylation wound; rna methylation; wound healing ... See more keywords
The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26495-2
Abstract: Despite recent advances in understanding skin scarring, mechanisms triggering hypertrophic scar formation are still poorly understood. In the present study, we investigate mature human hypertrophic scars and developing scars in mice at single cell resolution.… read more here.
Keywords: dipeptidyl peptidase; scar; serine proteases; scar formation ... See more keywords