The Effect of MMP-1 on Wound Healing and Scar Formation
Sign Up to like & getrecommendations! Published in 2021 at "Aesthetic Plastic Surgery"
DOI: 10.1007/s00266-021-02369-2
Abstract: In this study, we investigated the effect of matrix metalloproteinase-1 (MMP-1) on wound healing on skin in a model produced in rats. Sixteen Sprague–Dawley male rats were included in the study. The four full-thickness skin… read more here.
Keywords: wound healing; group; mmp; formation ... See more keywords
Smad interacting protein 1 influences transforming growth factor-β1/Smad signaling in extracellular matrix protein production and hypertrophic scar formation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-019-09844-w
Abstract: The transforming growth factor (TGF)-β/Smad signal transduction pathway is closely associated with hypertrophic scar (HS) formation. Smad interacting protein 1 (SIP1) is a cytoplasmic protein that efficiently regulates Smad2-/3-dependent signaling within the TGF-β1 pathway. SIP1… read more here.
Keywords: protein; transforming growth; smad; scar formation ... See more keywords
Use of Lasers in Wound Healing: How to Best Utilize Laser Technology to Prevent Scar Formation
Sign Up to like & getrecommendations! Published in 2018 at "Current Dermatology Reports"
DOI: 10.1007/s13671-018-0240-y
Abstract: Purpose of ReviewThe purpose of this review is to evaluate the efficacy of early intervention in wound healing on scar formation across multiple scar types and progressions. The types of scars consist of hypertrophic, atrophic,… read more here.
Keywords: wound healing; treatment; laser; scar formation ... See more keywords
Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.03.161
Abstract: It is of great clinical significance to design wound dressing materials with combined excellent wound healing properties and superior capability to suppress hypertrophic scar formation. This study aimed to examine if and how the cationicity… read more here.
Keywords: wound healing; hypertrophic scar; chitosan; scar formation ... See more keywords
TGN‐020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.03.007
Abstract: Aims: Identifying drugs that inhibit edema and glial scar formation and increase neuronal survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2‐(nicotinamide)‐1,3,4‐thiadiazole (TGN‐020), a potent selective inhibitor of aquaporin… read more here.
Keywords: glial scar; spinal cord; scar formation; tgn 020 ... See more keywords
Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.
Sign Up to like & getrecommendations! Published in 2018 at "Ophthalmology"
DOI: 10.1016/j.ophtha.2018.01.004
Abstract: PURPOSE To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN Multicenter, prospective cohort study. PARTICIPANTS A total of… read more here.
Keywords: fibrotic scar; scar; scar formation; ahr versus ... See more keywords
The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26495-2
Abstract: Despite recent advances in understanding skin scarring, mechanisms triggering hypertrophic scar formation are still poorly understood. In the present study, we investigate mature human hypertrophic scars and developing scars in mice at single cell resolution.… read more here.
Keywords: dipeptidyl peptidase; scar; serine proteases; scar formation ... See more keywords
Biodegradable hydrogels with photodynamic antibacterial activity promote wound healing and mitigate scar formation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01493a
Abstract: Bacterial proliferation and the disordered extracellular matrix (ECM) at the wound site are the major reasons for delayed healing and abnormal scarring. The development of new multifunctional dressing materials that can effectively prevent scar formation… read more here.
Keywords: scar; scar formation; antibacterial activity; wound healing ... See more keywords
FTY720 hinders IFN-γ-mediated fibrotic scar formation and facilitates neurological recovery after spinal cord injury.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0387
Abstract: Following spinal cord injury (SCI), fibrotic scar inhibits axon regeneration and impairs neurological function recovery. It has been reported that T cell-derived IFN-γ plays a pivotal role in promoting fibrotic scarring in neurodegenerative disease. However,… read more here.
Keywords: fibrotic scar; fty720; scar formation; spinal cord ... See more keywords
Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation.
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DOI: 10.1089/wound.2016.0709
Abstract: Significance: Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Recent Advances: Advances in our understanding… read more here.
Keywords: mechanical forces; minimize scar; wound environment; scar formation ... See more keywords
Effects of Rhinoplasty on Smile Esthetic and Gingival Appearance: Commentary.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Craniofacial Surgery"
DOI: 10.1097/scs.0000000000006677
Abstract: skin wound healing following trauma or surgery is imperfect and results in scar formation. We have read with interest the metaanalysis of Chen et al about the effectiveness and safety of botulinum toxin type a… read more here.
Keywords: wound healing; btx; scar formation; scar ... See more keywords