Plasma Metabolomic and Lipidomic Profiling of a Genetically Modified Mouse Model of Scavenger Receptor Class B Type I.
Sign Up to like & getrecommendations! Published in 2020 at "Proteomics"
DOI: 10.1002/pmic.202000050
Abstract: Atherosclerosis is a chronic inflammatory disease of the arterial wall and is becoming the principal cause of death globally. The reverse cholesterol transport (RCT) mediated by scavenger receptor class B type I (SR-BI) is a… read more here.
Keywords: receptor class; class type; scavenger receptor;
Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer’s disease pathophysiology
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.12.007
Abstract: Late onset Alzheimer disease's (LOAD) main risk factor is aging. Although it is not well known which age-related factors are involved in its development, evidence points out to the involvement of an impaired amyloid-β (Aβ)… read more here.
Keywords: microglia astrocytes; response; alzheimer disease; scavenger receptor ... See more keywords
Design and Synthesis of PEG-Oligoglycerol Sulfates as Multivalent Inhibitors for the Scavenger Receptor LOX-1.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01416
Abstract: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a cell surface scavenger receptor. The protein is involved in binding and internalization of oxidized low-density lipoprotein (oxLDL), which leads under pathophysiological circumstances to plaque formation in arteries… read more here.
Keywords: design synthesis; receptor lox; lox; scavenger receptor ... See more keywords
Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms16035
Abstract: The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role… read more here.
Keywords: receptor; responses pathogen; scavenger receptor; pathogen infection ... See more keywords
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15700-3
Abstract: Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show… read more here.
Keywords: large scale; scale multicenter; scavenger receptor; rheumatoid arthritis ... See more keywords
Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201443119
Abstract: Significance Atherosclerosis underpins the progression of stroke and myocardial infarction, both leading causes of death globally. Gene therapy is an emerging therapeutic approach for atherosclerosis, but the delivery of gene cargoes to the atherosclerotic plaque… read more here.
Keywords: targeted plaque; receptor targeted; atherosclerosis; scavenger receptor ... See more keywords
Scavenger receptor class BI (SR-BI) mediates uptake of CPX-351 into K562 leukemia cells
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1513026
Abstract: Abstract Purpose: CPX-351 is a liposomal formulation of cytarabine and daunorubicin encapsulated at a 5:1 molar ratio, for the treatment of acute myeloid leukemia. The Scavenger Receptor class B type I (SR-BI) plays an important… read more here.
Keywords: k562; receptor class; uptake cpx; cpx 351 ... See more keywords
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2072729
Abstract: ABSTRACT Introduction Scavenger receptor A (SR-A) is reported to be involved in innate and adaptive immunity and in recent years, the soluble form of SR-A has also been identified. Intriguingly, SR-A displays double-edged sword features… read more here.
Keywords: scavenger receptor; immunity autoimmune; autoimmune diseases; targeted therapy ... See more keywords
TFEB-dependent autophagy is involved in scavenger receptor OLR1/LOX-1-mediated tumor progression
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.2012970
Abstract: ABSTRACT Macroautophagy/autophagy is an evolutionarily conserved catabolic pathway required to maintain cellular homeostasis. In cancer, the tumor cell-intrinsic effects of autophagy are highly context specific, which could promote cancer cell survival or induce programmed cell… read more here.
Keywords: tumor; cancer; olr1 lox; cell ... See more keywords
O16: TARGETING THE LOX-1 SCAVENGER RECEPTOR ATTENUATES ATHEROSCLEROSIS AND NEOINTIMAL HYPERPLASIA IN APO-E NULL TRANSGENIC MICE
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Surgery"
DOI: 10.1093/bjs/znab117.016
Abstract: The clinical consequences of atherosclerosis and post-procedure neointimal hyperplasia (NIH) represent a significant proportion of the vascular surgeon's workload. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a class E scavenger receptor expressed in endothelial… read more here.
Keywords: scavenger receptor; mice; neointimal hyperplasia; lox ... See more keywords
High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010203
Abstract: Abstract Scavenger receptor class B type I (SR-B1) is highly expressed in a variety of cancers, including prostate, breast and ovarian. However, the relationship between SR-B1 and lung adenocarcinoma is unknown. We analyzed the expression… read more here.
Keywords: lung adenocarcinoma; class type; expression; scavenger receptor ... See more keywords