Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22801
Abstract: Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients… read more here.
Keywords: carcinoma head; cell carcinoma; squamous cell; expression ... See more keywords
KDM5B promotes metastasis and epithelial–mesenchymal transition via Wnt/β‐catenin pathway in squamous cell carcinoma of the head and neck
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23695
Abstract: Metastasis determines clinical management decision and restricts the therapeutic efficiency in patients with squamous cell carcinoma of the head and neck (SCCHN). Epigenetic factor KDM5B serves as an oncogene in multiple cancers. However, its role… read more here.
Keywords: kdm5b; catenin pathway; scchn; wnt catenin ... See more keywords
Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-2410
Abstract: Purpose: Platinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum(II), CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure.… read more here.
Keywords: treatment; clonal selection; cddp; resistance ... See more keywords
Abstract CT009: IMvoke010: A phase III, double-blind randomized trial of atezolizumab (atezo) after definitive local therapy vs placebo in patients (pts) with high-risk locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-ct009
Abstract: Background: Treatment (tx) for LA SCCHN includes a combination of surgery, radiation and/or chemotherapy followed by monitoring for local recurrence/distant metastases as standard of care. Given poor outcomes, there remains a clear unmet need in… read more here.
Keywords: scchn; inv efs; high risk; placebo ... See more keywords
Immunotherapy in head and neck cancer: aiming at EXTREME precision
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DOI: 10.1186/s12916-017-0879-4
Abstract: BackgroundLocoregionally advanced, recurrent, and metastatic squamous cell carcinomas of the head and neck (SCCHN) remain difficult to treat disease entities, in which systemic treatment often forms an integral part of their management. Immunotherapy is based… read more here.
Keywords: immunotherapy; treatment; head neck; cancer ... See more keywords
Phase I study of induction chemoimmunotherapy (ICI) with cemiplimab in combination with cisplatin and docetaxel (TPI) in patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN).
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e18116
Abstract: e18116 Background: To enhance patients' quality of life and prolong their survival, exploring an effective, low-toxicity version of the induction regimen for LA SCCHN is crucial. The addition of immunotherapy to cisplatin and docetaxel (TP)… read more here.
Keywords: patients completed; scchn; cisplatin docetaxel; cemiplimab ... See more keywords
Recurrent Versus Metastatic Head and Neck Cancer: An Evolving Landscape and the Role of Immunotherapy
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DOI: 10.3390/biomedicines12092080
Abstract: Squamous cell carcinoma of the head and neck (SCCHN) is among the ten most common cancers worldwide, with advanced SCCHN presenting with a 5-year survival of 34% in the case of nodal involvement and 8%… read more here.
Keywords: head neck; versus metastatic; metastatic head; scchn ... See more keywords
Metabolic Plasticity and Combinatorial Radiosensitisation Strategies in Human Papillomavirus-Positive Squamous Cell Carcinoma of the Head and Neck Cell Lines
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DOI: 10.3390/cancers13194836
Abstract: Simple Summary A subset of head and neck cancers (SCCHN) are caused by human papillomavirus (HPV). As these tumours tend to affect younger patients and are associated with favourable survival, there is a pressing need… read more here.
Keywords: cell lines; treatment; head neck; hpv positive ... See more keywords
Concordance, Correlation, and Clinical Impact of Standardized PD-L1 and TIL Scoring in SCCHN
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DOI: 10.3390/cancers14102431
Abstract: Simple Summary In patients with relapsed or metastasized squamous cell cancer of the head and neck (R/M SCCHN), the PD-L1 Combined Positive Score (CPS) is currently the only predictive biomarker for treatment with anti-PD-1 agents.… read more here.
Keywords: concordance; cps; impact; scchn ... See more keywords