Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck
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DOI: 10.1002/mc.22801
Abstract: Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients… read more here.
Keywords: carcinoma head; cell carcinoma; squamous cell; expression ... See more keywords
Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection
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DOI: 10.1158/1078-0432.ccr-17-2410
Abstract: Purpose: Platinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum(II), CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure.… read more here.
Keywords: treatment; clonal selection; cddp; resistance ... See more keywords
Immunotherapy in head and neck cancer: aiming at EXTREME precision
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DOI: 10.1186/s12916-017-0879-4
Abstract: BackgroundLocoregionally advanced, recurrent, and metastatic squamous cell carcinomas of the head and neck (SCCHN) remain difficult to treat disease entities, in which systemic treatment often forms an integral part of their management. Immunotherapy is based… read more here.
Keywords: immunotherapy; treatment; head neck; cancer ... See more keywords
Metabolic Plasticity and Combinatorial Radiosensitisation Strategies in Human Papillomavirus-Positive Squamous Cell Carcinoma of the Head and Neck Cell Lines
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DOI: 10.3390/cancers13194836
Abstract: Simple Summary A subset of head and neck cancers (SCCHN) are caused by human papillomavirus (HPV). As these tumours tend to affect younger patients and are associated with favourable survival, there is a pressing need… read more here.
Keywords: cell lines; treatment; head neck; hpv positive ... See more keywords
Concordance, Correlation, and Clinical Impact of Standardized PD-L1 and TIL Scoring in SCCHN
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DOI: 10.3390/cancers14102431
Abstract: Simple Summary In patients with relapsed or metastasized squamous cell cancer of the head and neck (R/M SCCHN), the PD-L1 Combined Positive Score (CPS) is currently the only predictive biomarker for treatment with anti-PD-1 agents.… read more here.
Keywords: concordance; cps; impact; scchn ... See more keywords