Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102009
Abstract: Triggering factors of Acute Chest Syndrome (ACS) is a leading cause of death in patients with Sickle Cell Disease (SCD) and targeted therapies are limited. Chlorine (Cl2) inhalation happens frequently, but its role as a… read more here.
Keywords: hemopexin; hemolysis; scd mice; mice ... See more keywords
A No-Lysis Flow Cytometry Protocol to Characterize Heterotypic Aggregates with Red Blood Cells in Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734374
Abstract: Sickle Cell Disease (SCD) is an inherited hemoglobinopathy characterized by a pro-inflammatory, pro-thrombotic phenotype. Platelet-leukocyte aggregates (PLAs), a hallmark of thrombo-inflammatory diseases, are elevated in SCD. While neutrophils play a role in aggregate formation, little… read more here.
Keywords: lysis protocol; scd mice; lysis; physiology ... See more keywords
Loss of FXR Signaling Promotes Chronic Liver Injury in Sickle Cell Disease
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DOI: 10.1182/blood-2020-143330
Abstract: Hepatic crisis is an emergent complication affecting sickle cell disease (SCD) patients, however, the molecular mechanism of sickle cell hepatobiliary crisis remains poorly understood. We have used intravital imaging to show that sinusoidal ischemia occurs… read more here.
Keywords: fxr signaling; scd mice; liver injury; injury ... See more keywords
Impaired Hepcidin Metabolism Promotes Hemolysis Induced Hepatobiliary Injury in Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143357
Abstract: Sickle cell disease (SCD) is an autosomal-recessive-genetic disorder that affects millions of people worldwide. Although hepatic crisis affects 10-40% of hospitalized SCD patients and can progress to fatal liver failure, the current treatment is primarily… read more here.
Keywords: scd; scd mice; mice; iron ... See more keywords