Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.06.015
Abstract: BACKGROUND & AIMS We investigated the functional role and clinical significance of stearoyl-CoA desaturase-1 (SCD1) mediated endoplasmic reticulum (ER) stress in regulating liver tumor-initiating cells (T-ICs) and sorafenib resistance, with the aim of developing a… read more here.
Keywords: scd1; liver ics; stress; sorafenib resistance ... See more keywords
CRISPR/Cas9-mediated Stearoyl-CoA Desaturase 1 (SCD1) Deficiency Affects Fatty Acid Metabolism in Goat Mammary Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b03545
Abstract: Stearoyl-CoA desaturase 1 (SCD1) is a fatty acid desaturase catalyzing cis-double-bond formation in the Δ9 position to produce monounsaturated fatty acids essential for the synthesis of milk fat. Previous studies using RNAi methods have provided… read more here.
Keywords: desaturase; crispr cas9; goat mammary; fatty acid ... See more keywords
Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate.
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2018.07.032
Abstract: BACKGROUND & AIMS The enzyme stearoyl-coenzyme A desaturase 1 (SCD or SCD1) produces monounsaturated fatty acids by introducing double bonds into saturated bonds between carbons 9 and 10, with oleic acid as the main product.… read more here.
Keywords: intestinal epithelium; oleic acid; mice; scd1 ... See more keywords
Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0369
Abstract: Activation of ferroptosis, a recently described mechanism of regulated cell death, dramatically inhibits growth of ovarian cancer cells. Given the importance of lipid metabolism in ferroptosis and the key role of lipids in ovarian cancer,… read more here.
Keywords: cell death; ovarian cancer; cancer; scd1 ... See more keywords
Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression
Sign Up to like & getrecommendations! Published in 2018 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-018-0762-0
Abstract: BackgroundThe prevalence of nonalcoholic fatty liver disease (NAFLD) has increased worldwide. Metformin decreases triglyceride (TG) accumulation in hepatocytes in vivo and in vitro. Stearyl-coenzyme A desaturase 1 (SCD1) knockout mice also show decreased liver TG… read more here.
Keywords: accumulation; metformin; expression; hepg2 cells ... See more keywords
SCD1 promotes lipid mobilization in subcutaneous white adipose tissue.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of lipid research"
DOI: 10.1194/jlr.ra120000869
Abstract: Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they are regulated deserves more explorations. In this study,… read more here.
Keywords: adipose tissue; white adipose; scd1; lipid mobilization ... See more keywords
Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0215083
Abstract: Introduction Adipose tissue is considered an important metabolic tissue, in charge of energy storage as well as being able to act in systemic homeostasis and inflammation. Epigenetics involves a series of factors that are important… read more here.
Keywords: promoter; tissue; h3k4me3; adipose tissue ... See more keywords
DNMT3a promotes osteoblast differentiation and alleviates osteoporosis via the PPARγ/SCD1/GLUT1 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Epigenomics"
DOI: 10.2217/epi-2021-0391
Abstract: Background: This study was designed to elucidate the role of DNMT3a and PPARγ functions in postmenopausal osteoporosis. Materials & methods: Mice were ovariectomized to establish an in vivo osteoporosis model and MC3T3-E1-14 osteoblasts were induced to… read more here.
Keywords: ppar; dnmt3a; osteoblast differentiation; postmenopausal osteoporosis ... See more keywords
Antidiabetic Effect of Rehmanniae Radix Based on Regulation of TRPV1 and SCD1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.875014
Abstract: Purpose: This study aimed to disclose the antidiabetic mechanisms of Rehmanniae Radix (RR). Methods: The antidiabetic effect of RR was studied in Streptozocin (STZ)–induced diabetes mellitus (DM) rats and HepG2 cells with insulin resistance (IR).… read more here.
Keywords: pharmacology; antidiabetic effect; group; trpv1 ... See more keywords
Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding and Unbinding Mechanism: A Computational Study
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11101435
Abstract: Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum… read more here.
Keywords: desaturase scd1; stearoyl coa; sequential dynamics; scd1 ... See more keywords
Stearoyl CoA Desaturase-1 Silencing in Glioblastoma Cells: Phospholipid Remodeling and Cytotoxicity Enhanced upon Autophagy Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113014
Abstract: Modulation of lipid metabolism is a well-established cancer hallmark, and SCD1 has been recognized as a key enzyme in promoting cancer cell growth, including in glioblastoma (GBM), the deadliest brain tumor and a paradigm of… read more here.
Keywords: inhibition; glioblastoma; increase; stearoyl coa ... See more keywords