Anaplasma phagocytophilum effector EgeA facilitates infection by hijacking TANGO1 and SCFD1 from ER–Golgi exit sites to pathogen-occupied inclusions
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2405209121
Abstract: Significance Anaplasma phagocytophilum, which lives in eukaryotic cells, causes human granulocytic anaplasmosis, a potentially severe to fatal disease. Host proteins TANGO1 and SCFD1 allow transport vesicles to accommodate bulky cargos, thereby preventing traffic congestion at… read more here.
Keywords: tango1 scfd1; exit sites; anaplasma phagocytophilum; scfd1 ... See more keywords
Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion
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DOI: 10.1080/15548627.2022.2064624
Abstract: ABSTRACT SCFD1 (sec1 family domain containing 1) was recently shown to function in autophagosome-lysosome fusion, and multiple studies have demonstrated the regulatory impacts of acetylation (a post-translational modification) on macroautophagy/autophagy. Here, we demonstrate that both… read more here.
Keywords: lysosome fusion; acetylation; scfd1; autophagosome lysosome ... See more keywords