Secretagogin in the brain and pituitary of the catfish, Clarias batrachus: Molecular characterization and regulation by insulin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25311
Abstract: Secretagogin (scgn), is a novel hexa EF‐hand, phylogenetically conserved calcium‐binding protein. It serves as Ca2+ sensor and participates in Ca2+‐signaling and neuroendocrine regulation in mammals. However, its relevance in the brain of non‐mammalian vertebrates has… read more here.
Keywords: brain pituitary; clarias batrachus; brain; scgn ... See more keywords
A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa142
Abstract: Excessive accumulation of cholesterol in β cells initiates endoplasmic reticulum (ER) stress and associated apoptosis. We have reported that excessive uptake of cholesterol by MIN6 cells decreases the expression of secretagogin (SCGN) and then attenuates… read more here.
Keywords: apoptosis; atf4; cell apoptosis; scgn ... See more keywords
ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.2139/ssrn.4024106
Abstract: Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN)… read more here.
Keywords: cell; secretagogin; apoptosis; min6 cells ... See more keywords