Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100622
Abstract: Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses a major threat. Recently, histone deacetylase 8… read more here.
Keywords: phenotypic screening; schistosoma mansoni; histone deacetylase; hdac inhibitors ... See more keywords
Genotypic-specific heat shock response of vector susceptibility to Schistosoma mansoni.
Sign Up to like & getrecommendations! Published in 2022 at "Ecosphere"
DOI: 10.1002/ecs2.4207
Abstract: Living organisms are vulnerable to thermal stress which causes a diversity of physiological outcomes. Previous work has shown that the snail vectors (Biomphalaria glabrata) of an important human pathogen, Schistosoma mansoni, revert from resistant to… read more here.
Keywords: schistosoma mansoni; heat; heat shock;
Size-asymmetric competition among snails disrupts production of human-infectious Schistosoma mansoni cercariae.
Sign Up to like & getrecommendations! Published in 2021 at "Ecology"
DOI: 10.1002/ecy.3383
Abstract: Parasites can harm hosts and influence populations, communities, and ecosystems. However, parasites are reciprocally affected by population- and community-level dynamics. Understanding feedbacks between infection dynamics and larger scale epidemiological and ecological processes could improve predictions… read more here.
Keywords: competition among; production; size; competition ... See more keywords
Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847858
Abstract: The helminth Schistosoma mansoni (S. mansoni) induces a network of regulatory immune cells, including interleukin (IL)‐10‐producing regulatory B cells (Bregs). However, the signals required for the development and activation of Bregs are not well characterized.… read more here.
Keywords: mansoni; type interferons; ifn; schistosoma mansoni ... See more keywords
Schistosoma mansoni and soil transmtted helminths in olive baboons and potential zoonosis
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.495
Abstract: Abstract Zoonotic pathogens are among the most important causes of ill health all over the world. The presence of these pathogens in free ranging baboons may have significant implications for humans. In Kenya, the encroachment… read more here.
Keywords: mansoni soil; soil transmtted; olive baboons; transmtted helminths ... See more keywords
Structural and Functional Characterization of Schistosoma mansoni Cathepsin B1.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_12
Abstract: Schistosomiasis caused by parasitic blood flukes of the genus Schistosoma is a global health problem with over 200 million people infected. Schistosoma mansoni cathepsin B1 (SmCB1) is a gut-associated protease critical for digestion of host blood… read more here.
Keywords: functional characterization; smcb1; structural functional; schistosoma mansoni ... See more keywords
Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_14
Abstract: Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride channels from Schistosoma mansoni, a… read more here.
Keywords: gated chloride; glutamate gated; chloride channels; schistosoma mansoni ... See more keywords
Biophysical Analysis of Schistosoma mansoni Septins.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_16
Abstract: Septins are dynamic filament-forming proteins that are recognized as important components of the cytoskeleton and are involved in numerous functions inside the cells, such as cytokinesis, exocytosis, and ciliogenesis and even in defense against pathogenic… read more here.
Keywords: analysis schistosoma; biology; schistosoma mansoni; biophysical analysis ... See more keywords
Proteomic Analysis of Schistosoma mansoni Tegumental Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_8
Abstract: The tegument (outer surface) of Schistosoma mansoni and other trematodes is in intimate contact with the host and plays an important role in host-parasite interactions. It is a complex structure that contains hundreds of proteins… read more here.
Keywords: schistosoma mansoni; analysis schistosoma; proteomic analysis; tegumental proteins ... See more keywords
Measuring Histone Modifications in the Human Parasite Schistosoma mansoni.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0635-3_9
Abstract: DNA-binding proteins play critical roles in many major processes such as development and sexual biology of Schistosoma mansoni and are important for the pathogenesis of schistosomiasis. Chromatin immunoprecipitation (ChIP) experiments followed by sequencing (ChIP-seq) are… read more here.
Keywords: histone modifications; biology; schistosoma mansoni; measuring histone ... See more keywords
High-resolution AP-SMALDI MSI as a tool for drug imaging in Schistosoma mansoni
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03230-w
Abstract: Schistosoma mansoni is a parasitic flatworm causing schistosomiasis, an infectious disease affecting several hundred million people worldwide. Schistosomes live dioeciously, and upon pairing with the male, the female starts massive egg production, which causes pathology.… read more here.
Keywords: drug imaging; drug; smaldi msi; schistosoma mansoni ... See more keywords