Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis
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DOI: 10.1002/cmdc.201800238
Abstract: Schistosomiasis is a neglected parasitic disease that affects more than 265 million people worldwide and for which the control strategy relies on mass treatment with only one drug: praziquantel. Based on the 3‐chlorobenzothiophene‐2‐hydroxamic acid J1075,… read more here.
Keywords: schistosomiasis; treatment; crystallization studies; studies vitro ... See more keywords
Rationale and design of a screening study to detect schistosomiasis‐associated pulmonary hypertension in Ethiopia and Zambia
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DOI: 10.1002/pul2.12072
Abstract: Abstract Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH) worldwide, but the prevalence and risk factors for schistosomiasis‐associated PAH (SchPAH) development are not well understood. Schistosomiasis‐associated hepatosplenic disease (SchHSD) is thought to be… read more here.
Keywords: screening study; hypertension; schistosomiasis associated; schistosomiasis ... See more keywords
Thrombocytopenia, splenomegaly, and periportal fibrosis in a migrant
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DOI: 10.1007/s00277-022-04838-3
Abstract: Dear Editor, Hepatosplenic schistosomiasis (HSS) is an underdiagnosed complication of chronic schistosomal infection which can lead to severe portal hypertensive complications if left untreated. We present a case of thrombocytopenia and splenomegaly secondary to undiagnosed… read more here.
Keywords: thrombocytopenia splenomegaly; schistosomiasis; fibrosis; splenomegaly ... See more keywords
Schistosomiasis—from immunopathology to vaccines
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DOI: 10.1007/s00281-020-00789-x
Abstract: Schistosomiasis (bilharzia) is a neglected tropical disease caused by trematode worms of the genus Schistosoma . The transmission cycle involves human (or other mammalian) water contact with surface water contaminated by faeces or urine, as… read more here.
Keywords: schistosomiasis; schistosomiasis immunopathology; immunopathology; disease ... See more keywords
Sigmoid colon cancer due to Schistosomiasis
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DOI: 10.1007/s15010-019-01331-4
Abstract: A 76-year-old female patient with a history of bloody stools and abdominal discomfort underwent colonoscopy, showing a severe stenosing process. After surgical resection, histological analysis revealed an intermediate-grade adenocarcinoma (3.5 × 3 cm) pTNM: pT4a,… read more here.
Keywords: cancer due; schistosomiasis; sigmoid colon; colon cancer ... See more keywords
Prevalence-based modeling approach of schistosomiasis: global stability analysis and integrated control assessment
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DOI: 10.1007/s40314-021-01414-9
Abstract: A system of nonlinear differential equations is proposed to assess the effects of prevalence-dependent disease contact rate, pathogen’s shedding rates, and treatment rate on the dynamics of schistosomiasis in a general setting. The decomposition techniques… read more here.
Keywords: schistosomiasis; analysis; rate; integrated control ... See more keywords
Urogenital Schistosomiasis—Evidence-Based Benefits of Treatment Initiated Early During Childhood
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DOI: 10.1007/s40588-017-0077-3
Abstract: Purpose of ReviewUrogenital schistosomiasis, caused by the helminth parasite Schistosoma haematobium, is one of the most important childhood public health problems in Africa, compromising child growth and development and usually causing irreversible damage in life… read more here.
Keywords: schistosomiasis; childhood; treatment; urogenital schistosomiasis ... See more keywords
Treatment of human and livestock helminth infections in a mobile pastoralist setting at Lake Chad: Attitudes to health and analysis of active pharmaceutical ingredients of locally available anthelminthic drugs.
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DOI: 10.1016/j.actatropica.2016.05.012
Abstract: Mobile pastoralists face challenges in accessing quality health care and medication for managing human and animal diseases. We determined livestock disease priorities, health seeking behaviour of people bearing helminthiases and - placing particular emphasis on… read more here.
Keywords: schistosomiasis; anthelminthic drugs; livestock; treatment ... See more keywords
Nanotechnology as a potential therapeutic alternative for schistosomiasis.
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DOI: 10.1016/j.actatropica.2017.06.025
Abstract: Schistosomiasis is a neglected disease that affects millions of people worldwide, recognized as the most important human helminth infection in terms of morbidity and mortality. The treatment of choice presents low bioavailability and water solubility,… read more here.
Keywords: schistosomiasis; alternative schistosomiasis; nanotechnology potential; potential therapeutic ... See more keywords
The epidemiology of schistosomiasis in Lango region Uganda 60 years after Schwetz 1951: Can schistosomiasis be eliminated through mass drug administration without other supportive control measures?
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DOI: 10.1016/j.actatropica.2018.06.009
Abstract: INTRODUCTION Lango region is the only known endemic region for urinary and intestinal schistosomiasis in Uganda. Although there has been no significant improvement in sanitation and safe water supply in the region over years, the… read more here.
Keywords: schistosomiasis; control; epidemiology; haematobium ... See more keywords
Effectiveness of vinpocetine and isosorbide-5-mononitrate on experimental schistosomiasis mansoni: Biochemical and immunohistochemical study.
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DOI: 10.1016/j.actatropica.2018.06.010
Abstract: Schistosomiasis is one of the most important tropical and subtropical devastating diseases, where praziquantel is the sole drug of choice. Praziquantel effectively kills the adult worms, however, drug resistance has been repeatedly reported. Moreover, there… read more here.
Keywords: schistosomiasis; vinpocetine isosorbide; biochemical immunohistochemical; mononitrate ... See more keywords