What It Will Take to Make Coordinated Specialty Care Available to Anyone Experiencing Early Schizophrenia: Getting Over the Hump
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2016.2665
Abstract: Schizophrenia is a brain disorder with a lifetime prevalence near 1% that is associated with high levels of functional impairment and low expectations for recovery.1 Only 10% to 15% of people with schizophrenia work. The… read more here.
Keywords: csc; schizophrenia; health; csc programs ... See more keywords
Assessment of Insulin Resistance Among Drug-Naive Patients With First-Episode Schizophrenia in the Context of Hormonal Stress Axis Activation
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2017.1983
Abstract: Before the introduction of antipsychotics, links between schizophrenia and abnormal glucose metabolism levels were found in the late 1800s as an increased prevalence of diabetes in families with a history of “insanity.”1 Furthermore, it is… read more here.
Keywords: among drug; schizophrenia; first episode; insulin resistance ... See more keywords
Effectiveness, Core Elements, and Moderators of Response of Cognitive Remediation for Schizophrenia
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2021.0620
Abstract: Key Points Question What is the effectiveness of cognitive remediation on cognition and functioning in people diagnosed with schizophrenia, and what are its active ingredients? Findings In this systematic review and meta-analysis, cognitive remediation was… read more here.
Keywords: effectiveness core; schizophrenia; core elements; cognitive remediation ... See more keywords
Association of Mitochondrial Biogenesis With Variable Penetrance of Schizophrenia.
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DOI: 10.1001/jamapsychiatry.2021.0762
Abstract: Importance Discovery of mechanisms that underlie variable penetrance for neuropsychiatric illness in the context of genetic variants that carry elevated risk can advance novel treatment approaches for these disorders. Objective To test the hypothesis that… read more here.
Keywords: variable penetrance; 22q group; mitochondrial biogenesis; schizophrenia ... See more keywords
Association Between Retinal Features From Multimodal Imaging and Schizophrenia.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2023.0171
Abstract: Importance The potential association of schizophrenia with distinct retinal changes is of clinical interest but has been challenging to investigate because of a lack of sufficiently large and detailed cohorts. Objective To investigate the association… read more here.
Keywords: association retinal; multimodal imaging; patients schizophrenia; retinal features ... See more keywords
ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease
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DOI: 10.1002/bies.201700054
Abstract: Activity‐dependent neuroprotective protein (ADNP), discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism‐like… read more here.
Keywords: schizophrenia; alzheimer disease; autism; adnp plays ... See more keywords
Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia
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DOI: 10.1002/brb3.1355
Abstract: This study investigates the expression of mRNA encoding vasopressin in the hypothalamus of autopsy brains of individuals diagnosed with schizophrenia. read more here.
Keywords: schizophrenia; hypothalamus; expression; expression vasopressin ... See more keywords
Separating scale‐free and oscillatory components of neural activity in schizophrenia
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DOI: 10.1002/brb3.2047
Abstract: Alterations in narrow‐band spectral power of electroencephalography (EEG) recordings are commonly reported in patients with schizophrenia (SZ). It is well established however that electrophysiological signals comprise a broadband scale‐free (or fractal) component generated by mechanisms… read more here.
Keywords: neural activity; schizophrenia; scale free; free oscillatory ... See more keywords
Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia
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DOI: 10.1002/brb3.2535
Abstract: Abnormal brain network connectivity is strongly implicated in the pathogenesis of schizophrenia. The striatum, consisting of the caudate and putamen, is the major treatment target for antipsychotics, the primary treatments for schizophrenia; however, there are… read more here.
Keywords: connectivity; connectivity striatum; drug naive; functional connectivity ... See more keywords
A Synergistic Examination of Excitatory‐Inhibitory Balance in First‐Episode Schizophrenia Merging 7‐Tesla Magnetic Resonance Spectroscopic Imaging and Magnetoencephalography
Sign Up to like & getrecommendations! Published in 2025 at "Brain and Behavior"
DOI: 10.1002/brb3.70735
Abstract: Excitatory/inhibitory (E/I) imbalance is a proposed neural disruption in schizophrenia supported by magnetic resonance spectroscopic imaging (MRSI) evidence of altered gamma‐aminobutyric acid (GABA) and glutamate (Glu) levels. However, there exists a paucity of data linking… read more here.
Keywords: schizophrenia; excitatory inhibitory; first episode; spectroscopic imaging ... See more keywords
Different shades of default mode disturbance in schizophrenia: Subnodal covariance estimation in structure and function
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DOI: 10.1002/hbm.23870
Abstract: Schizophrenia is a devastating mental disease with an apparent disruption in the highly associative default mode network (DMN). Interplay between this canonical network and others probably contributes to goal‐directed behavior so its disturbance is a… read more here.
Keywords: schizophrenia; network; default mode; dmn ... See more keywords