Imputed expression of schizophrenia‐associated genes and cognitive measures in patients with schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1942
Abstract: Cognitive dysfunction is a core manifestation of schizophrenia and one of the best predictors of long‐term disability. Genes increasing risk for schizophrenia may partly act through the modulation of cognition. read more here.
Keywords: genes cognitive; associated genes; imputed expression; schizophrenia associated ... See more keywords
Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01146-6
Abstract: Reduced activity of the mediodorsal thalamus (MD) and abnormal functional connectivity of the MD with the prefrontal cortex (PFC) cause cognitive deficits in schizophrenia. However, the molecular basis of MD hypofunction in schizophrenia is not… read more here.
Keywords: schizophrenia associated; synaptic function; schizophrenia; mediodorsal thalamus ... See more keywords
The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain
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DOI: 10.1038/s41380-022-01490-1
Abstract: A missense mutation (A391T) in SLC39A8 is strongly associated with schizophrenia in genomic studies, though the molecular connection to the brain is unknown. Human carriers of A391T have reduced serum manganese, altered plasma glycosylation, and… read more here.
Keywords: glycosylation; schizophrenia; schizophrenia associated; protein glycosylation ... See more keywords
Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia
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DOI: 10.1371/journal.pone.0200278
Abstract: A number of loci are associated with highly heritable schizophrenia and the prevalence of this mental illness has had considerable negative fitness effects on human populations. Here we focused on one particular schizophrenia-associated gene that… read more here.
Keywords: schizophrenia associated; st8sia2 gene; schizophrenia; positive selection ... See more keywords