HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia‐like animals
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25914
Abstract: Although histone acetylation is one of the most widely studied epigenetic modifications, there is still a lack of information regarding how the acetylome is regulated during brain development and pathophysiological processes. We demonstrate that the… read more here.
Keywords: h3k9; schizophrenia like; acetylation; differentiation ... See more keywords
Metformin attenuates antipsychotic-induced metabolic dysfunctions in MK801-induced schizophrenia-like rats
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05524-w
Abstract: Rationale Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced… read more here.
Keywords: schizophrenia like; mk801 induced; olanzapine risperidone; metabolic dysfunctions ... See more keywords
A proof-of-concept study of maternal immune activation mediated induction of Toll-like receptor (TLR) and inflammasome pathways leading to neuroprogressive changes and schizophrenia-like behaviours in offspring
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.06.009
Abstract: Infection, particularly prenatal infection, leads to an enhanced risk of schizophrenia in the offspring. Interestingly, few data exist on the pathway(s) such as TLR and inflammasome, primarily involved in sensing the microorganisms and inducing downstream… read more here.
Keywords: schizophrenia like; like behaviours; infection; inflammasome pathways ... See more keywords
4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114864
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Scrophularia buergeriana has been used for traditional medicine as an agent for reducing heat in the blood and for nourishing kidney 'Yin'. Therefore, S. buergeriana might be a potential treatment for mental illness,… read more here.
Keywords: schizophrenia like; methoxycinnamic acid; like behaviors; behaviors induced ... See more keywords
Involvement of NLRP3 inflammasome in schizophrenia-like behaviour in young animals after maternal immune activation
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropsychiatrica"
DOI: 10.1017/neu.2020.27
Abstract: Abstract Objective: To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour in young animals exposed to maternal immune activation (MIA). Methods: To this aim, on the 15th gestational… read more here.
Keywords: nlrp3 inflammasome; schizophrenia like; like behaviour; inflammasome schizophrenia ... See more keywords
Association between risk of dementia and very late-onset schizophrenia-like psychosis: a Swedish population-based cohort study.
Sign Up to like & getrecommendations! Published in 2021 at "Psychological medicine"
DOI: 10.1017/s0033291721002099
Abstract: BACKGROUND Although the incidence of psychotic disorders among older people is substantial, little is known about the association with subsequent dementia. We aimed to examine the rate of dementia diagnosis in individuals with very late-onset… read more here.
Keywords: diagnosis; schizophrenia like; late onset; onset schizophrenia ... See more keywords
Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0755-3
Abstract: Schizophrenia is a debilitating disorder affecting young adults displaying symptoms of cognitive impairment, anxiety, and early social isolation prior to episodes of auditory hallucinations. Cannabis use has been tied to schizophrenia-like symptoms, indicating that dysregulated… read more here.
Keywords: schizophrenia like; pyramidal neurons; like behaviors; ptp1b ... See more keywords
The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia Research"
DOI: 10.1101/2022.03.25.485752
Abstract: Background and Hypothesis Schizophrenia research arose in the last decades, focusing more on its neural basis. Executive functions such as decision making and cognitive flexibility are the main cognitive areas that are impaired and are… read more here.
Keywords: cognitive inflexibility; model; like cognitive; schizophrenia like ... See more keywords
Fingolimod ameliorates schizophrenia‐like cognitive impairments induced by phencyclidine in male rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15954
Abstract: Improvement of cognitive deficits in schizophrenia remains an unmet need owing to the lack of new therapies and drugs. Recent studies have reported that fingolimod, an immunomodulatory drug for treating multiple sclerosis, demonstrates anti‐inflammatory and… read more here.
Keywords: impairments induced; ameliorates schizophrenia; fingolimod ameliorates; like cognitive ... See more keywords
Diosmin attenuates schizophrenia-like behavior, oxidative stress, and acetylcholinesterase activity in mice
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2020-0119
Abstract: Abstract Objectives Diosmin (DSM), commonly isolated from various plants, is a citrus nutrient that has been shown to increase intracellular antioxidant capacity and assuage symptoms associated with neurological disorders. Deficiency in the antioxidant system has… read more here.
Keywords: schizophrenia like; activity; like behavior; oxidative stress ... See more keywords
Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update
Sign Up to like & getrecommendations! Published in 2020 at "Current Neuropharmacology"
DOI: 10.2174/1570159x18666200814175114
Abstract: Background Schizophrenia is a serious mental illness that affects more than 21 million people worldwide. Both genetics and the environment play a role in its etiology and pathogenesis. Symptoms of schizophrenia are mainly categorized into… read more here.
Keywords: schizophrenia like; animal models; behavioral tasks; like behaviors ... See more keywords