Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21686
Abstract: Antipsychotic drugs are the preferred choice for schizophrenia treatment; however, response is highly variable. In the context of the search for predictors of antipsychotic treatment effectiveness, the evaluation of response within 2 weeks has been indicated… read more here.
Keywords: response; association; schizophrenia patients; risperidone ... See more keywords
Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug‐naïve first‐episode schizophrenia patients with auditory verbal hallucinations
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.25958
Abstract: Numerous studies indicate altered static local and long‐range functional connectivity of multiple brain regions in schizophrenia patients with auditory verbal hallucinations (AVHs). However, the temporal dynamics of interhemispheric and intrahemispheric functional connectivity patterns remain unknown… read more here.
Keywords: dfcd; functional connectivity; schizophrenia patients; interhemispheric intrahemispheric ... See more keywords
Morphological fingerprinting: Identifying patients with first‐episode schizophrenia using auto‐encoded morphological patterns
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26098
Abstract: Although a large number of case–control statistical and machine learning studies have been conducted to investigate structural brain changes in schizophrenia, how best to measure and characterize structural abnormalities for use in classification algorithms remains… read more here.
Keywords: encoded morphological; episode schizophrenia; first episode; auto encoded ... See more keywords
Correlation of BDNF, VEGF, TNF‐α, and S100B with cognitive impairments in chronic, medicated schizophrenia patients
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DOI: 10.1002/npr2.12261
Abstract: Cognitive impairment is a prominent cause of disability in schizophrenia. Although antipsychotic drugs can rescue the psychotic symptoms, the cognitive impairments persist, with no treatment available. Alterations of BDNF, VEGF, TNF‐α, and S100B have been… read more here.
Keywords: tnf; schizophrenia patients; vegf tnf; bdnf vegf ... See more keywords
A Clinical Study Protocol to Identify Serum Biomarkers Predictive of Response to Antipsychotics in Schizophrenia Patients.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-52479-5_21
Abstract: An increasing number of studies are now exploring the potential of using blood-based biomarkers for prediction of antipsychotic treatment response in studies of schizophrenia patients. Here we describe the detailed setup of a clinical study… read more here.
Keywords: response; study; protocol identify; clinical study ... See more keywords
An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5134-y
Abstract: RationaleSchizophrenia is associated with impairments in cognitive functioning yet there are no approved drugs to treat these deficits.ObjectivesBased on animal models, we investigated the potential for roflumilast, a selective inhibitor of phosphodiesterase type 4 (PDE4),… read more here.
Keywords: medicine; working memory; schizophrenia patients; roflumilast ... See more keywords
Neural correlates of binocular depth inversion illusion in antipsychotic-naïve first-episode schizophrenia patients
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-018-0886-2
Abstract: ObjectivesBinocular depth inversion illusion (BDII), a visual, ‘top–down’-driven information process, is impaired in schizophrenia and particularly in its early stages. BDII is a sensitive measure of impaired visual information processing and represents a valid diagnostic… read more here.
Keywords: schizophrenia; first episode; gyrus; depth inversion ... See more keywords
Meta-analysis of physical activity and effects of social function and quality of life on the physical activity in patients with schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-018-0903-5
Abstract: Schizophrenia patients have increased mortality and morbidity, mainly due to premature cardiovascular disease resulting from decreased physical activity (PA). However, which PA intensity is impaired in the patients and how factors such as social function… read more here.
Keywords: social function; schizophrenia patients; schizophrenia; physical activity ... See more keywords
Analysis of COMT Val158Met polymorphisms and methylation in Chinese male schizophrenia patients with homicidal behavior
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-018-1773-0
Abstract: Schizophrenia is a severe mental disorder, and its mechanisms have not been fully elucidated. A functional single nucleotide polymorphism (SNP) present in the catechol-O-methyltransferase (COMT) gene, Val158Met (rs4680) (Chr22: 19,963,498), is possibly related to the… read more here.
Keywords: methylation; schizophrenia; homicidal behavior; val158met rs4680 ... See more keywords
Impact of ageing on the brain regions of the schizophrenia patients: an fMRI study using evolutionary approach
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DOI: 10.1007/s11042-020-09183-z
Abstract: Schizophrenia is a mental disorder that results in adverse functional and biochemical changes in the brain. Although normal ageing significantly affects the brain of a person structurally as well as functionally, the functional activation pattern… read more here.
Keywords: methodology; study; brain regions; schizophrenia patients ... See more keywords
Abnormal synchronization of functional and structural networks in schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-019-00175-8
Abstract: Synchronization is believed to play an important role in information processing of the brain. Mounting evidence supports the hypothesis that schizophrenia is related to impaired neural synchrony. However, most previous studies characterize brain synchronization from… read more here.
Keywords: functional structural; networks schizophrenia; structural networks; schizophrenia patients ... See more keywords