SA102 A COGNITIVE AND MOLECULAR ANALYSIS OF SDCCAG8, A SCHIZOPHRENIA RISK GENE THAT FUNCTIONS IN THE CENTROSOME
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.174
Abstract: Background Schizophrenia affects 1% of adults and is a major global health problem. Although aetiology is complex, genetics represents a vital tool for probing the neurobiology of the disorder in the absence of biomarkers. We… read more here.
Keywords: sdccag8; schizophrenia; molecular analysis; schizophrenia risk ... See more keywords
Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
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DOI: 10.1038/s41467-019-08666-4
Abstract: Genome-wide association studies (GWASs) have identified over 180 independent schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer schizophrenia susceptibility remains largely unknown. Here we systematically investigate the gene regulatory mechanisms… read more here.
Keywords: schizophrenia; risk; schizophrenia risk; gene regulatory ... See more keywords
Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk
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DOI: 10.1038/s41467-020-16710-x
Abstract: Inhibitory interneurons orchestrate information flow across the cortex and are implicated in psychiatric illness. Although interneuron classes have unique functional properties and spatial distributions, the influence of interneuron subtypes on brain function, cortical specialization, and illness… read more here.
Keywords: schizophrenia risk; risk; brain; brain function ... See more keywords
Association between Tumor Necrosis factor-Alpha(TNF-a) polymorphisms and Schizophrenia: an updated meta-analysis.
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DOI: 10.1080/13651501.2021.2009879
Abstract: BACKGROUND Previous studies have explored associations between Tumour Necrosis factor-Alpha (TNF-a) polymorphisms and Schizophrenia. Their results were controversial. We conducted a meta-analysis to clarify the association between TNF-a - 308 G/A(rs1800629), -1031T/C(rs1799964), -863C/A(rs1800630) and -857 C/T (rs1799724) polymorphisms and… read more here.
Keywords: analysis; schizophrenia risk; polymorphisms schizophrenia; schizophrenia ... See more keywords
The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects
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DOI: 10.3389/fpsyg.2019.02218
Abstract: Although previous evidence has suggested that there is a genetic link between schizophrenia and creativity, the specific genetic variants that underlie the link are still largely unknown. To further explore the potential genetic link between… read more here.
Keywords: schizophrenia; schizophrenia risk; creativity; association ... See more keywords