Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response.
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DOI: 10.1038/s41416-021-01560-1
Abstract: BACKGROUND The absence of the putative DNA/RNA helicase Schlafen11 (SLFN11) is thought to cause resistance to DNA-damaging agents (DDAs) and PARP inhibitors. METHODS We developed and validated a clinically applicable SLFN11 immunohistochemistry assay and retrospectively… read more here.
Keywords: schlafen11 slfn11; retrospective analysis; response; slfn11 ... See more keywords