Tissue-engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28083
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons (MN). To investigate whether Schwann cells could be involved in the disease pathogenesis, we developed a tissue-engineered 3D in vitro… read more here.
Keywords: lateral sclerosis; engineered vitro; schwann cells; schwann ... See more keywords
Pals1a and aPKCλ are not essential for Schwann cell migration, division or myelination in zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.547
Abstract: Schwann cells (SCs) are specialized glial cells of the peripheral nervous system that produce myelin and promote fast action potential propagation. In order to myelinate, SCs engage in a series of events that include migration… read more here.
Keywords: myelination; pals1a apkc; migration division; schwann ... See more keywords
The TSC1‐mTOR‐PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage‐specific manner
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23449
Abstract: Proper peripheral myelination depends upon the balance between Schwann cell proliferation and differentiation programs. The serine/threonine kinase mTOR integrates various environmental cues to serve as a central regulator of cell growth, metabolism, and function. We… read more here.
Keywords: schwann; cell proliferation; schwann cell; mtor ... See more keywords
Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23527
Abstract: Of the seven P2X receptor subtypes, P2X4 receptor (P2X4R) is widely distributed in the central nervous system, including in neurons, astrocytes, and microglia. Accumulating evidence supports roles for P2X4R in the central nervous system, including… read more here.
Keywords: schwann; schwann cells; remyelination; p2x4r ... See more keywords
Piezo channels contribute to the regulation of myelination in Schwann cells
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DOI: 10.1002/glia.24251
Abstract: Peripheral nerves and Schwann cells have to sustain constant mechanical constraints, caused by developmental growth as well as stretches associated with movements of the limbs and mechanical compressions from daily activities. In Schwann cells, signaling… read more here.
Keywords: schwann cells; yap taz; schwann; regulation ... See more keywords
Modulation of Schwann cell homeostasis by the BAP1 deubiquitinase
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DOI: 10.1002/glia.24351
Abstract: Schwann cell programming during myelination involves transcriptional networks that activate gene expression but also repress genes that are active in neural crest/embryonic differentiation of Schwann cells. We previously found that a Schwann cell‐specific deletion of… read more here.
Keywords: bap1; schwann; injury; schwann cell ... See more keywords
Schwann cell‐specific RhoA knockout accelerates peripheral nerve regeneration via promoting Schwann cell dedifferentiation
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24365
Abstract: Our previous studies indicated that RhoA knockdown or inhibition could alleviate the proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in Schwann cells during nerve injury and repair is still unknown.… read more here.
Keywords: schwann cells; schwann; nerve; rhoa ... See more keywords
Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24610
Abstract: Schwann cells are critical for the proper development and function of the peripheral nervous system (PNS), where they form a collaborative relationship with axons. Past studies highlighted that a pair of proteins called the prohibitins… read more here.
Keywords: phb2; myelination; biology; schwann cell ... See more keywords
Schwann Cells Contribute to Alveolar Bone Regeneration by Promoting Cell Proliferation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4735
Abstract: The plasticity of Schwann cells (SCs) following nerve injury is a critical feature in the regeneration of peripheral nerves as well as surrounding tissues. Here, we show a pivotal role of Schwann cell‐derived cells in… read more here.
Keywords: regeneration; cell; alveolar bone; bone ... See more keywords
N‐acetylcysteine microparticles reduce cisplatin‐induced RSC96 Schwann cell toxicity
Sign Up to like & getrecommendations! Published in 2024 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.1256
Abstract: Cisplatin is known to cause inner ear dysfunction. There is growing evidence that cisplatin‐induced demyelination of spiral or Scarpa's ganglion neurons may play an additional role in drug‐induced ototoxicity alongside afferent neuron injury. As Schwann… read more here.
Keywords: acetylcysteine microparticles; schwann cell; schwann; cisplatin induced ... See more keywords
Extracellular matrix cues modulate Schwann cell morphology, proliferation, and protein expression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2987
Abstract: Peripheral nerve injuries require a complex set of signals from cells, macrophages, and the extracellular matrix (ECM) to induce regeneration across injury sites and achieve functional recovery. Schwann cells (SCs), the major glial cell in… read more here.
Keywords: schwann; extracellular matrix; proliferation; matrix cues ... See more keywords