Electrical Differentiation of Mesenchymal Stem Cells into Schwann‐Cell‐Like Phenotypes Using Inkjet‐Printed Graphene Circuits
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201601087
Abstract: Graphene-based materials (GBMs) have displayed tremendous promise for use as neurointerfacial substrates as they enable favorable adhesion, growth, proliferation, spreading, and migration of immobilized cells. This study reports the first case of the differentiation of… read more here.
Keywords: like phenotypes; differentiation mesenchymal; schwann cell; differentiation ... See more keywords
Few-Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell-Like Phenotypes.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502204
Abstract: This study investigates the potential of few-layered conductive graphene foams as 3D platforms for the electrical transdifferentiation of mesenchymal stem cells (MSCs) into Schwann cell (SC)-like phenotypes for peripheral nerve injury (PNI) treatment. The 3D… read more here.
Keywords: graphene foams; layered conductive; transdifferentiation; like phenotypes ... See more keywords
EGR3 Inhibits Tumor Progression by Inducing Schwann Cell‐Like Differentiation
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DOI: 10.1002/advs.202400066
Abstract: The mechanism and function of the expression of Schwann characteristics by nevus cells in the mature zone of the dermis are unknown. Early growth response 3 (EGR3) induces Schwann cell‐like differentiation of melanoma cells by… read more here.
Keywords: differentiation; egr3 inhibits; like differentiation; schwann cell ... See more keywords
EGR3 Inhibits Tumor Progression by Inducing Schwann Cell‐Like Differentiation (Adv. Sci. 34/2024)
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DOI: 10.1002/advs.202470207
Abstract: Schwann Cell‐Like Differentiation From left to right, the image shows lipid nanoparticles with CD86‐P2A‐EGR3 mRNA entering a melanoma cell, reprogramming it into a Schwann cell‐like melanoma cell with long protrusions, reduced migration, and CD86 receptor… read more here.
Keywords: egr3; like differentiation; schwann cell; cell ... See more keywords
Sulfatase‐mediated manipulation of the astrocyte‐Schwann cell interface
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DOI: 10.1002/glia.23047
Abstract: Schwann cell (SC) transplantation following spinal cord injury (SCI) may have therapeutic potential. Functional recovery is limited however, due to poor SC interactions with host astrocytes and the induction of astrogliosis. Olfactory ensheathing cells (OECs)… read more here.
Keywords: sulfatase mediated; sulfatase; astrocyte; schwann cell ... See more keywords
Schwann cell‐specific deletion of the endosomal PI 3‐kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2‐ErbB3 tyrosine kinase signaling
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DOI: 10.1002/glia.23173
Abstract: The PI 3‐kinase Vps34 (Pik3c3) synthesizes phosphatidylinositol 3‐phosphate (PI3P), a lipid critical for both endosomal membrane traffic and macroautophagy. Human genetics have implicated PI3P dysregulation, and endosomal trafficking in general, as a recurring cause of… read more here.
Keywords: vps34; schwann cell; kinase; myelination ... See more keywords
The TSC1‐mTOR‐PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage‐specific manner
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DOI: 10.1002/glia.23449
Abstract: Proper peripheral myelination depends upon the balance between Schwann cell proliferation and differentiation programs. The serine/threonine kinase mTOR integrates various environmental cues to serve as a central regulator of cell growth, metabolism, and function. We… read more here.
Keywords: schwann; cell proliferation; schwann cell; mtor ... See more keywords
Modulation of Schwann cell homeostasis by the BAP1 deubiquitinase
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DOI: 10.1002/glia.24351
Abstract: Schwann cell programming during myelination involves transcriptional networks that activate gene expression but also repress genes that are active in neural crest/embryonic differentiation of Schwann cells. We previously found that a Schwann cell‐specific deletion of… read more here.
Keywords: bap1; schwann; injury; schwann cell ... See more keywords
Schwann cell‐specific RhoA knockout accelerates peripheral nerve regeneration via promoting Schwann cell dedifferentiation
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DOI: 10.1002/glia.24365
Abstract: Our previous studies indicated that RhoA knockdown or inhibition could alleviate the proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in Schwann cells during nerve injury and repair is still unknown.… read more here.
Keywords: schwann cells; schwann; nerve; rhoa ... See more keywords
Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination
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DOI: 10.1002/glia.24610
Abstract: Schwann cells are critical for the proper development and function of the peripheral nervous system (PNS), where they form a collaborative relationship with axons. Past studies highlighted that a pair of proteins called the prohibitins… read more here.
Keywords: phb2; myelination; biology; schwann cell ... See more keywords
Schwann cell precursors generate sympathoadrenal system during zebrafish development
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24909
Abstract: The autonomic portion of the peripheral nervous system orchestrates tissue homeostasis through direct innervation of internal organs, and via release of adrenalin and noradrenalin into the blood flow. The developmental mechanisms behind the formation of… read more here.
Keywords: cell precursors; chromaffin cells; system; schwann cell ... See more keywords