Architecture‐Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration
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DOI: 10.1002/adhm.202202658
Abstract: The inflammatory cascade after spinal cord injury (SCI) causes necrotizing apoptosis of local stem cells, which limits nerve regeneration. Therefore, coordinating the inflammatory immune response and neural stem cell (NSC) functions is key to promoting… read more here.
Keywords: regeneration; sci; system; microenvironment ... See more keywords
TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1‐Mediated Neuronal PANoptosis in Spinal Cord Injury
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DOI: 10.1002/advs.202407132
Abstract: Spinal cord injury (SCI) is a severe injury to the central nervous system, and its treatment is always a major medical challenge. Proinflammatory cell death is considered an important factor affecting neuroinflammation and the prognosis… read more here.
Keywords: degradation; panoptosis; injury; zbp1 ... See more keywords
Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury.
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DOI: 10.1002/advs.202503966
Abstract: Due to an inhibitory scar microenvironment that prevents neural circuit reconstruction, spinal cord injury (SCI) often leads to persistent neurological dysfunction. Although neonatal murine models demonstrate that microglial inhibition enables scar remodeling to support neuroregeneration… read more here.
Keywords: circuit; circuit reconstruction; spinal cord; sci ... See more keywords
Repurposing of Chemokine Antagonists for Combined Phase-Resolved Spinal Cord Injury Treatment.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202516569
Abstract: Spinal cord injury (SCI) is a medical challenge that results in the formation of a glial scar preventing recovery of axonal conductivity. Cytokines and chemokines significantly affect the pathogenesis of SCI and represent important targets… read more here.
Keywords: spinal cord; cord injury; injury; sci ... See more keywords
Neuregulin‐1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury
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DOI: 10.1002/glia.23150
Abstract: Spinal cord injury (SCI) results in glial activation and neuroinflammation, which play pivotal roles in the secondary injury mechanisms with both pro‐ and antiregeneration effects. Presently, little is known about the endogenous molecular mechanisms that… read more here.
Keywords: recovery following; injury; sci; spinal cord ... See more keywords
Oligodendrocyte‐selective deletion of the eIF2α kinase Perk/Eif2ak3 limits functional recovery after spinal cord injury
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24525
Abstract: After spinal cord injury (SCI), re‐establishing cellular homeostasis is critical to optimize functional recovery. Central to that response is PERK signaling, which ultimately initiates a pro‐apoptotic response if cellular homeostasis cannot be restored. Oligodendrocyte (OL)… read more here.
Keywords: spinal cord; recovery; injury; perk ... See more keywords
Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats
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DOI: 10.1002/jcb.26392
Abstract: Spinal cord injury (SCI) is lead to locomotor impairment because of neurological damage after following trauma. Quercetin (Que) has been confirmed to have a neuro‐protective effect during nerve damage processes. The purpose of this study… read more here.
Keywords: sci; astrocyte activation; activation; damage ... See more keywords
Ferroptosis in Spinal Cord Injury: Research Progress and Novel Insights
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DOI: 10.1002/jcb.70067
Abstract: Spinal cord injury (SCI) is a severe condition affecting the central nervous system that often leads to varying degrees of motor and sensory impairment. Acute primary SCI is often managed with early surgical intervention; however,… read more here.
Keywords: spinal cord; cord injury; ferroptosis; research ... See more keywords
A potential entanglement between the spinal cord and hippocampus: Theta rhythm correlates with neurogenesis deficiency following spinal cord injury in male rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24719
Abstract: Cognitive deficits due to spinal cord injury (SCI) have been elucidated in both animals and humans with SCI. Such disorders may cause concomitant oscillatory changes in regions of the brain involving in cognition; a subject… read more here.
Keywords: theta; sci; theta rhythm; spinal cord ... See more keywords
Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24836
Abstract: Spinal cord injury (SCI) is a debilitating condition, which leads to a permanent loss of functions below the injury site. The events which take place after SCI are characterized by cellular death, release of inhibitory… read more here.
Keywords: sci; olfactory ensheathing; magnetic stimulation; transplantation ... See more keywords
Impact of injury duration on a sensorimotor functional network in complete spinal cord injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25069
Abstract: Connectivity changes after spinal cord injury (SCI) appear as dynamic post‐injury procedures. The present study aimed to investigate the alterations in the functional connectivity (FC) in different injury duration in complete SCI using resting‐state functional… read more here.
Keywords: sci; cord injury; sensorimotor; cortex ... See more keywords