Creating effective biocontainment facilities and maintenance protocols for raising specific pathogen-free, severe combined immunodeficient (SCID) pigs
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Animals"
DOI: 10.1177/0023677217750691
Abstract: Severe combined immunodeficiency (SCID) is defined by the lack of an adaptive immune system. Mutations causing SCID are found naturally in humans, mice, horses, dogs, and recently in pigs, with the serendipitous discovery of the… read more here.
Keywords: research; scid pigs; scid; biocontainment facilities ... See more keywords
Recombination activating gene-2null severe combined immunodeficient pigs and mice engraft human induced pluripotent stem cells differently
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20626
Abstract: This study comparatively investigated the transcriptional, physiological, and phenotypic differences of the immune disorder between severe combined immunodeficient (SCID) mouse and pig models. We discovered that the recombination activating gene-2 (Rag-2) SCID mice, but not… read more here.
Keywords: scid mice; scid pigs; rag scid; mice ... See more keywords
Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00559
Abstract: Within the last decade there have been several severe combined immunodeficient (SCID) pig models discovered or genetically engineered. The animals have mutations in ARTEMIS, IL2RG, or RAG1/2 genes, or combinations thereof, providing SCID pigs with… read more here.
Keywords: research; scid pig; scid pigs; scid ... See more keywords