Pharmacogenetics and Metabolism from Science to Implementation in Clinical Practice: The Example of Dihydropyrimidine Dehydrogenase.
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DOI: 10.2174/1381612823666170125155530
Abstract: BACKGROUND Fluoropyrimidines are widely used in the treatment of solid tumors and remain the backbone of many combination chemotherapy regimens. Despite their clinical benefit, they are associated with frequent gastrointestinal and hematological toxicities, which often… read more here.
Keywords: science implementation; dihydropyrimidine dehydrogenase; treatment; metabolism science ... See more keywords