The IncRNA SCIRT Promotes the Proliferative, Migratory, and Invasive Properties of Cervical Cancer Cells by Upregulating MMP-2/-9
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/3448224
Abstract: Objective The morbidity and mortality of cervical cancer (CC) rank the fourth-most common among cancers in females, seriously threatening women's health and affecting their quality of life. However, the molecular mechanism of CC development remains… read more here.
Keywords: cervical cancer; scirt; lncrna scirt; scirt knockdown ... See more keywords
SCIRT lncRNA Restrains Tumorigenesis by Opposing Transcriptional Programs of Tumor-Initiating Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-2612
Abstract: These findings show that a novel lncRNA SCIRT counteracts breast tumorigenesis by opposing transcriptional networks associated with cell cycle and self-renewal. In many tumors, cells transition reversibly between slow-proliferating tumor-initiating cells (TIC) and their differentiated,… read more here.
Keywords: scirt; tumorigenesis opposing; cell cycle; cell ... See more keywords
LncRNA SCIRT is Downregulated in Acute Myeloid Leukemia and Sponges miR-21 in Cytoplasm to Increase Chemosensitivity to Doxorubicin.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2021039618
Abstract: BACKGROUND This study aimed to explore the role of SCIRT in acute myeloid leukemia (AML) and its interaction with miR-21. METHODS This study included 66 AML patients who were diagnosed with AML and received doxorubicin… read more here.
Keywords: scirt; myeloid leukemia; scirt mir; acute myeloid ... See more keywords