Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
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DOI: 10.1126/scitranslmed.aam7785
Abstract: Infectious prions can be detected in the skin of patients with sporadic Creutzfeldt-Jakob disease. Prions in unexpected places Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, can be transmitted via neurosurgical instruments or… read more here.
Keywords: prion; skin; disease; seeding activity ... See more keywords
High-Depth PRNP Sequencing in Brains With Sporadic Creutzfeldt-Jakob Disease
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DOI: 10.1212/nxg.0000000000200054
Abstract: Background and Objectives Sporadic Creutzfeldt-Jakob disease (sCJD) has established genetic risk factors, but, in contrast to genetic and acquired CJD, the initial trigger for misfolded prion aggregation and spread is not known. In this study,… read more here.
Keywords: disease; creutzfeldt jakob; scjd; sporadic creutzfeldt ... See more keywords
Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis
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DOI: 10.1371/journal.ppat.1006802
Abstract: Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are restricted to ex vivo and animal models.… read more here.
Keywords: alterations mirna; machinery; disease; scjd ... See more keywords