Sclareol inhibits RANKL-induced osteoclastogenesis and promotes osteoblastogenesis through promoting CCN1 expression via repressing the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-020-09578-6
Abstract: Osteoclasts are crucial cellular components of bone and are the cause of various bone problems like osteoporosis. Various biological activities such as anti-tumorous, anti-inflammatory, antibacterial, and immunomodulatory function are influenced by Sclareol, as a natural… read more here.
Keywords: sclareol; mapk pathway; rankl induced; bone ... See more keywords
Comparative proteomic analyses of Hyphozyma roseonigra ATCC 20624 in response to sclareol
Sign Up to like & getrecommendations! Published in 2019 at "Brazilian Journal of Microbiology"
DOI: 10.1007/s42770-019-00040-2
Abstract: Sclareol is an important intermediate for ambroxide synthesis industries. Hyphozyma roseonigra ATCC 20624 was the only reported strain capable of degrading sclareol to the main product of sclareol glycol, which is the precursor of ambroxide.… read more here.
Keywords: atcc 20624; proteomic analyses; sclareol; roseonigra atcc ... See more keywords
SCLAREIN (SCLAREol contained in zeIN) nanoparticles: Development and characterization of an innovative natural nanoformulation.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.10.184
Abstract: Sclareol is a labdane diterpene which carries on a broad range of biological activities. However, its poor water solubility and bioavailability are the foremost drawbacks that limit its application in therapeutics. The purpose of this… read more here.
Keywords: sclareol; drug; sclareol contained; natural nanoformulation ... See more keywords
Sclareol purification using the supercritical fractionation process: A modeling case study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Supercritical Fluids"
DOI: 10.1016/j.supflu.2020.104754
Abstract: Abstract The aim of this study was to model experimental results obtained for the supercritical CO2 fractionation of a liquid mixture containing 24% of sclareol in order to recover a raffinate with increased sclareol content.… read more here.
Keywords: sclareol; fractionation; extract compositions; study ... See more keywords
Abstract 10: Sclareol induces apoptosis and inhibits notch signaling in hamster oral carcinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-10
Abstract: The Notch signaling pathway is an evolutionarily conserved cell signaling pathway. It plays a central role in cell fate decisions and differentiation. The bioavailability of sclareol has been widely studied due to its anti-carcinogenic and… read more here.
Keywords: sclareol; dmba; sclareol induces; notch signaling ... See more keywords
Anti-Candida Potential of Sclareol in Inhibiting Growth, Biofilm Formation, and Yeast–Hyphal Transition
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Fungi"
DOI: 10.3390/jof9010098
Abstract: Even though Candida albicans commonly colonizes on most mucosal surfaces including the vaginal and gastrointestinal tract, it can cause candidiasis as an opportunistic infectious fungus. The emergence of resistant Candida strains and the toxicity of… read more here.
Keywords: anti candida; candida potential; biofilm formation; anti fungal ... See more keywords
Supercritical Fluid Extraction of Essential Oil and Sclareol from a Clary Sage Concrete
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093903
Abstract: Clary Sage extracts are of industrial interest: in particular, sclareol shows a strong pharmaceutical potential. Supercritical fluid extraction was used to recover compounds of interest from a Salvia sclarea L. waxy n-hexane extract (“concrete”), using… read more here.
Keywords: clary sage; extraction; supercritical fluid; fluid extraction ... See more keywords
Phytosterols Are Involved in Sclareol-Induced Chlorophyll Reductions in Arabidopsis
Sign Up to like & getrecommendations! Published in 2023 at "Plants"
DOI: 10.3390/plants12061282
Abstract: Sclareol, a diterpene, has a wide range of physiological effects on plants, such as antimicrobial activity; disease resistance against pathogens; and the expression of genes encoding proteins involved in metabolism, transport, and phytohormone biosynthesis and… read more here.
Keywords: sclareol; induced chlorophyll; campesterol stigmasterol; arabidopsis ... See more keywords