Identification of RUNX1T1 as a potential epigenetic modifier in small‐cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12829
Abstract: Small‐cell lung cancer (SCLC) can be subgrouped into common ‘pure’ and rare ‘combined’ SCLC (c‐SCLC). c‐SCLC features a mixed tumor histology of both SCLC and non–small‐cell lung cancer (NSCLC). We performed targeted exome sequencing on… read more here.
Keywords: cell; small cell; sclc; lung cancer ... See more keywords
UHRF1 plays an oncogenic role in small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23493
Abstract: Small cell lung cancer (SCLC) is a malignant tumor characterized by aggressiveness and dismal prognosis. The specific role of ubiquitin‐like PHD and RING finger domain (UHRF1), a frequently overexpressed cancer‐promoting gene in various tumors, is… read more here.
Keywords: uhrf1; role; sclc; small cell ... See more keywords
The impact of symptoms and comorbidity on health utility scores and health-related quality of life in small cell lung cancer using real world data
Sign Up to like & getrecommendations! Published in 2020 at "Quality of Life Research"
DOI: 10.1007/s11136-020-02615-1
Abstract: Small cell lung cancer (SCLC) is a highly fatal disease associated with significant morbidity, with a need for real-world symptom and health utility score (HUS) data. HUS can be measured using an EQ-5D-5L questionnaire, however… read more here.
Keywords: hus; health utility; sclc; comorbidity ... See more keywords
Cost-Effectiveness Analysis of Anlotinib as Third- or Further-Line Treatment for Relapsed Small Cell Lung Cancer (SCLC) in China
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DOI: 10.1007/s12325-021-01889-2
Abstract: The survival of patients with relapsed small cell lung cancer (SCLC) has achieved little progress in the last several decades. ALTER1202 confirmed the efficacy and safety of anlotinib as a third- or further-line option for… read more here.
Keywords: cost effectiveness; cost; sclc; third line ... See more keywords
Notch pathway in small-cell lung cancer: from preclinical evidence to therapeutic challenges
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Oncology"
DOI: 10.1007/s13402-019-00441-3
Abstract: BackgroundSmall-cell lung cancer (SCLC) is an aggressive disease with still limited therapeutic options. Despite being both a chemo- and radiation-sensitive malignancy, SCLC recurrence occurs in most cases and negatively impacts patients’ prognosis. Over the last… read more here.
Keywords: sclc; cell lung; lung cancer; notch pathway ... See more keywords
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.09.008
Abstract: Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, respectively). To define the heterogeneity of tumors and their associated… read more here.
Keywords: sclc; cell lung; cancer; cell ... See more keywords
FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice
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DOI: 10.1016/j.celrep.2020.02.052
Abstract: Summary Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other lung tumors has remained elusive. Here, we assess the tumorigenic capacity of… read more here.
Keywords: sclc; origin sclc; cell origin; fgfr1 ... See more keywords
CLINICAL AND GENOMIC CHARACTERISTICS OF SMALL CELL LUNG CANCER IN NEVER-SMOKERS: RESULTS FROM A RETROSPECTIVE MULTICENTER COHORT STUDY.
Sign Up to like & getrecommendations! Published in 2020 at "Chest"
DOI: 10.1016/j.chest.2020.04.068
Abstract: BACKGROUND Small cell lung cancer (SCLC) has the strongest association with smoking among lung cancers. The characteristics of never-smokers with SCLC is not known. RESEARCH QUESTION Is the clinical characteristics, prognostic factors, survival, genomic alterations,… read more here.
Keywords: never smokers; sclc; study; lung cancer ... See more keywords
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.005
Abstract: Small cell lung cancer (SCLC) is a rapidly lethal disease with few therapeutic options. We studied metabolic heterogeneity in SCLC to identify subtype-selective vulnerabilities. Metabolomics in SCLC cell lines identified two groups correlating with high… read more here.
Keywords: sclc; monophosphate dehydrogenase; cell lung; inosine monophosphate ... See more keywords
Small-cell lung cancer in never smokers: The clinicopathological features including the prognosis
Sign Up to like & getrecommendations! Published in 2017 at "Cancer treatment and research"
DOI: 10.1016/j.ctarc.2017.04.001
Abstract: Abstract Background Small-cell lung cancer (SCLC) is known to be closely associated with smoking; therefore, never-smokers with SCLC are very rare. We conducted a retrospective study to investigate the clinicopathological features of SCLC in never-smokers.… read more here.
Keywords: sclc; never smokers; cell lung; lung cancer ... See more keywords
An open-label, phase II study of the polo-like kinase-1 (Plk-1) inhibitor, BI 2536, in patients with relapsed small cell lung cancer (SCLC).
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2016.12.019
Abstract: OBJECTIVES This phase II, open-label study was designed to evaluate the response rate to the polo-like kinase 1 (Plk-1) inhibitor BI 2536 in patients with sensitive-relapsed small cell lung cancer (SCLC). Secondary endpoints included progression-free… read more here.
Keywords: open label; sclc; study; lung cancer ... See more keywords