Effect of Regulating the Expression of HSP47 on Collagen Metabolism in Scleral Fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "Current Eye Research"
DOI: 10.1080/02713683.2020.1805471
Abstract: ABSTRACT Purpose To explore the effect of heat shock protein 47 (HSP 47) on collagen (types I, III, and V) metabolism in scleral fibroblasts. Methods Scleral fibroblasts with over- or low-expression of HSP 47 were… read more here.
Keywords: collagen; hsp; metabolism scleral; scleral fibroblasts ... See more keywords
Regulation of Matrix Metalloproteinase-2 Secretion from Scleral Fibroblasts and Retinal Pigment Epithelial Cells by miR-29a
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DOI: 10.1155/2017/2647879
Abstract: Purpose To identify an effective method to prevent myopia progression by characterizing the regulation of matrix metalloproteinase- (MMP-) 2 expression and its secretion from scleral fibroblasts and retinal pigment epithelium (RPE) cells by miR-29a. Methods… read more here.
Keywords: fibroblasts rpe; mir 29a; secretion scleral; rpe cells ... See more keywords
Effect of TGF-β2 on the Mechanical Properties of Posterior Scleral Fibroblasts in Experimental Myopia
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DOI: 10.1155/2022/6193876
Abstract: Objective The effects of TGF-β2 on mechanical properties of sclerotic desmocytes isolated from healthy and myopic guinea pigs were investigated in order to further understand the pathogenesis of myopia. To study the effect of TGF-β2… read more here.
Keywords: properties posterior; effect tgf; scleral fibroblasts; mechanical properties ... See more keywords
A Potential Research Target for Scleral Remodeling: Effect of MiR-29a on Scleral Fibroblasts
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DOI: 10.1159/000525189
Abstract: Introduction: The purpose of this study was to determine whether miR-29a regulates cell survival and apoptosis and the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), MMP-2, and collagen I in scleral… read more here.
Keywords: inhibitor; expression; group; mir 29a ... See more keywords
NANOG improves type I collagen expression in human fetal scleral fibroblasts
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DOI: 10.2298/abs180711048l
Abstract: Human fetal scleral fibroblasts (HFSFs) are components of the sclera and play important roles in its structure and function. In myopia, scleral remodeling reduces collagen fibers and the sclera begins to thin. NANOG is a… read more here.
Keywords: expression; human fetal; nanog improves; collagen ... See more keywords
Angiotensin II-Related Activation of Scleral Fibroblasts and Their Role on Retinal Ganglion Cell Death in Glaucoma
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DOI: 10.3390/ph16040556
Abstract: We identify the angiotensin II (AngII)-associated changes in the extracellular matrix (ECM) and the biomechanical properties of the sclera after systemic hypotension. Systemic hypotension was induced by administering oral hydrochlorothiazide. AngII receptor levels and ECM… read more here.
Keywords: hypotension; cell; systemic hypotension; sclera systemic ... See more keywords