Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45010
Abstract: Scleraxis (Scx) is a basic helix-loop-helix transcription factor that is expressed persistently in tendons/ligaments, but transiently in entheseal cartilage. In this study, we generated a novel ScxCre knock-in (KI) allele, by in-frame replacement of most… read more here.
Keywords: scleraxis; expression; maturation; cre ... See more keywords
Scleraxis and fibrosis in the pressure-overloaded heart.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac362
Abstract: AIMS In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo is unknown. The present study… read more here.
Keywords: fibroblast activation; scleraxis; heart; fibrosis ... See more keywords
Role of scleraxis in angiotensin II-induced cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5725178
Abstract: Cardiac fibrosis involves the activation and conversion of fibroblasts to myofibroblasts in response to pathophysiological stresses, resulting in structural and functional remodeling of the heart leading to heart failure and death. Although it affects millions… read more here.
Keywords: cardiac fibrosis; expression; physiology; scleraxis ... See more keywords
Scleraxis Alters Arterial Smooth Muscle Phenotypic Switching and Exacerbates Arterial Stiffness
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5728710
Abstract: Arterial stiffness (AS) is an impairment in arterial relaxation and function in blood pressure regulation and is associated with the development of multiple cardiovascular diseases including hypertension, atherosclerosis, and adverse outcomes such as stroke, heart… read more here.
Keywords: arterial stiffness; physiology; scleraxis; smooth muscle ... See more keywords