Next-generation sequencing in the evaluation of biliary strictures in patients with primary sclerosing cholangitis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cytopathology"
DOI: 10.1002/cncy.22528
Abstract: BACKGROUND Primary sclerosing cholangitis (PSC) is a well-described risk factor for the development of cholangiocarcinoma (CCA). Early detection of CCA in these patients is of great importance because it expands options for therapeutic interventions, including… read more here.
Keywords: biliary strictures; cytology; primary sclerosing; next generation ... See more keywords
Diagnostic pitfalls and the value of fluorescence in situ hybridization as an adjunct to cytologic evaluation of bile duct brushings in patients with primary sclerosing cholangitis
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25059
Abstract: Primary sclerosing cholangitis (PSC) can present diagnostic difficulties on bile duct brushings as cytologic features mimicking adenocarcinoma may exist. This study evaluates the role of fluorescence in‐situ hybridization (FISH) as an adjunct to cytologic evaluation. read more here.
Keywords: situ hybridization; sclerosing cholangitis; fluorescence situ; primary sclerosing ... See more keywords
Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30061
Abstract: In the multidrug resistance protein 2 (Mdr2)‐/‐ mouse model, low phospholipid bile instigates biliary epithelial injury, sterile inflammation, and fibrosis, thereby recapitulating disease mechanisms implicated in biliary atresia (BA) and primary sclerosing cholangitis. We hypothesize… read more here.
Keywords: fibrosis murine; cd8 lymphocytes; cd8; fibrosis ... See more keywords
Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30085
Abstract: Improved methods are needed to risk stratify and predict outcomes in patients with primary sclerosing cholangitis (PSC). Therefore, we sought to derive and validate a prediction model and compare its performance to existing surrogate markers.… read more here.
Keywords: risk; psc; risk estimate; presto ... See more keywords
Antiprogrammed Cell Death‐1 Immunotherapy‐Related Secondary Sclerosing Cholangitis
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30189
Abstract: Secondary sclerosing cholangitis (SSC) is a rare disease that is associated with various etiologies. Recent development of immune checkpoint inhibitors demonstrates efficacy in the treatment of various malignancies; however, these inhibitors can also cause immune-related… read more here.
Keywords: antiprogrammed cell; cell death; secondary sclerosing; sclerosing cholangitis ... See more keywords
Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30210
Abstract: Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy frequently complicated by cholangiocarcinoma (CCA). Massive proliferation of biliary tree stem/progenitor cells (BTSCs), expansion of peribiliary glands (PBGs), and dysplasia were observed in PSC. The aims… read more here.
Keywords: cca; primary sclerosing; stem; cell ... See more keywords
Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30237
Abstract: Lysyl oxidase like‐2 (LOXL2) plays a central role in fibrogenesis and is elevated in the serum and liver of patients with primary sclerosing cholangitis (PSC). We evaluated the safety and efficacy of simtuzumab, a monoclonal… read more here.
Keywords: clinical events; disease; primary sclerosing; placebo ... See more keywords
Reply to HEP-20-0140 Letter to the Editors: Could Butyrate Be Incorporated With Farnesoid X Receptor Agonist Cilofexor to Enhance Primary Sclerosing Cholangitis Treatment?
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31268
Abstract: We thank Drs. Chen and Vitetta for their letter regarding our manuscript describing our phase 2 study of the nonsteroidal farnesoid X receptor (FXR) agonist cilofexor in non-cirrhotic patients with primary sclerosing cholangitis (PSC).1 As… read more here.
Keywords: letter; primary sclerosing; sclerosing cholangitis; agonist cilofexor ... See more keywords
Steroid therapy still plays a crucial role and could serve as a bridge to the next promising treatments in patients with IgG4-related sclerosing cholangitis: Results of a Japanese Nationwide Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepato-biliary-pancreatic sciences"
DOI: 10.1002/jhbp.1157
Abstract: OBJECTIVE The acceptable duration of steroid therapy for patients with IgG4-sclerosing cholangitis (SC) has been under debate. Our aim is to clarify the feasible duration of steroid treatment. DESIGN We retrospectively reviewed the data of… read more here.
Keywords: steroid therapy; therapy; patients igg4; sclerosing cholangitis ... See more keywords
Colectomy in patients with ulcerative colitis is not associated to future diagnosis of primary sclerosing cholangitis.
Sign Up to like & getrecommendations! Published in 2023 at "United European gastroenterology journal"
DOI: 10.1002/ueg2.12388
Abstract: BACKGROUND Primary Sclerosing Cholangitis (PSC) is a hepatobiliary disease closely related to ulcerative colitis (UC). In PSC patients, colectomy has been linked to improved prognosis, especially following liver transplantation. This suggests an involvement of the… read more here.
Keywords: colectomy; diagnosis; sclerosing cholangitis; psc ... See more keywords
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9420-5_24
Abstract: Cholangiopathies, including primary sclerosing cholangitis, are a group of heterogeneous diseases characterized by inflammation and fibrosis of the intrahepatic and extrahepatic bile duct epithelium. Studies, especially of primary sclerosing cholangitis, have been hampered by the… read more here.
Keywords: derived organoids; method; study; primary sclerosing ... See more keywords