Considering the Future of Pediatric Multiple Sclerosis Trials After the CONNECT Open-Label Randomized Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.30451
Abstract: The approach to treatment of relapsing-remitting multiple sclerosis (RRMS) is rapidly evolving, with more than 15 disease-modifying therapies (DMTs) currently licensed for adults. Current treatment algorithms in children with multiple sclerosis (MS) remain heavily reliant… read more here.
Keywords: sclerosis; future pediatric; considering future; trial ... See more keywords
Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.4284
Abstract: Importance Individuals with tuberous sclerosis complex can develop a progressive neuropsychiatric syndrome known as tuberous sclerosis-associated neuropsychiatric disorders. Tuberous sclerosis-associated neuropsychiatric disorders symptoms overlap with clinical criteria for frontotemporal dementia, yet the association between the… read more here.
Keywords: sclerosis; tuberous sclerosis; frontotemporal dementia; sclerosis associated ... See more keywords
Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2024.0017
Abstract: This cohort study examines data from 2 prospective multiple sclerosis cohorts to identify cerebrospinal fluid measures associated with relapsing and nonrelapsing progressive multiple sclerosis pathobiology. read more here.
Keywords: multiple sclerosis; cerebrospinal fluid; sclerosis; emerging cerebrospinal ... See more keywords
Infectious risk stratification in multiple sclerosis patients receiving immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.491
Abstract: The increasing number of potent treatments for multiple sclerosis warrants screening for infections. To investigate the prevalence of infections in two independent German patient cohorts with multiple sclerosis/neuromyelitis optica spectrum disorders (NMOSD), we performed a… read more here.
Keywords: sclerosis; risk stratification; multiple sclerosis; stratification multiple ... See more keywords
Multiple sclerosis clinical decision support system based on projection to reference datasets
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51649
Abstract: Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. read more here.
Keywords: multiple sclerosis; clinical decision; decision support; sclerosis ... See more keywords
Remyelination varies between and within lesions in multiple sclerosis following bexarotene
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51662
Abstract: In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexarotene versus placebo in 49 people with… read more here.
Keywords: sclerosis; varies within; remyelination varies; multiple sclerosis ... See more keywords
COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51688
Abstract: The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment. We aimed to assess… read more here.
Keywords: risk alzheimer; sclerosis; alzheimer disease; covid ... See more keywords
Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51717
Abstract: Neurodegeneration induced by inflammatory stress in multiple sclerosis (MS) leads to long‐term neurological disabilities that are not amenable to current immunomodulatory therapies. read more here.
Keywords: sclerosis; cns neurons; downregulation sf3b2; sf3b2 protects ... See more keywords
Correspondence of MRI and nTMS With EDSS in Multiple Sclerosis: Longitudinal Follow‐Up Study
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70041
Abstract: Considering the characteristics of multiple sclerosis (MS) disease and its impact on motor disability, this study aims to assess the functional integrity of the corticospinal tract by examining motor evoked potentials (MEPs), Expanded Disability Status… read more here.
Keywords: multiple sclerosis; edss; sclerosis; mri ntms ... See more keywords
Ethnic and Socioeconomic Associations with Multiple Sclerosis Risk
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25688
Abstract: Epidemiological research in multiple sclerosis (MS) has mainly been performed in socioeconomically and ethnically limited populations; influences on MS risk have not been studied in prospectively collected non‐White populations. We set out to study the… read more here.
Keywords: sclerosis; associations multiple; risk; ethnic socioeconomic ... See more keywords
Reduction in Cognitive Processing Speed Surrounding Multiple Sclerosis Relapse
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26301
Abstract: The purpose of this study was to explore the longitudinal relationship between multiple sclerosis (MS) relapses and information processing efficiency among persons with relapsing–remitting MS. read more here.
Keywords: cognitive processing; sclerosis; processing speed; reduction cognitive ... See more keywords