Overview of Lipid Biomarkers in Amyotrophic Lateral Sclerosis (ALS).
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-21735-8_18
Abstract: Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease involving motor neuron (MN) degeneration in the spinal cord, brain stem and primary motor cortex. The existence of inflammatory processes around MN and axonal degeneration in… read more here.
Keywords: lipid biomarkers; amyotrophic lateral; overview lipid; sclerosis als ... See more keywords
Phenotypic differences of amyotrophic lateral sclerosis (ALS) in China and Germany
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DOI: 10.1007/s00415-018-8735-9
Abstract: ObjectiveThe aim of this study is to explore phenotypical differences of amyotrophic lateral sclerosis (ALS) between two cohorts from Germany and China.MethodsRegistry-based studies of ALS were conducted in South-West Germany from 2010 to 2014 and… read more here.
Keywords: amyotrophic lateral; als patients; sclerosis als; differences amyotrophic ... See more keywords
In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS)
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02238-0
Abstract: Amyotrophic lateral sclerosis (ALS) is a form of motor neuron disease (MND) that is characterized by the progressive loss of motor neurons within the spinal cord, brainstem, and motor cortex. Although ALS clinically manifests as… read more here.
Keywords: protein; bifc; formation; amyotrophic lateral ... See more keywords
P350 Amyotrophic lateral sclerosis (ALS) a disease when neurophysiology is an essential tool even in the 21th century
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2017.07.358
Abstract: Objectives ALS is a progressive neurodegenerative disease. Our aim was to examine the correlation of the severity of symptoms and the findings of electromyography (EMG), electroneurography (ENG) and to find parameters in estimating prognosis. Methods… read more here.
Keywords: patients referred; p350 amyotrophic; amyotrophic lateral; sclerosis als ... See more keywords
Implication of HMGB1 signaling pathways in Amyotrophic lateral sclerosis (ALS): From molecular mechanisms to pre-clinical results.
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DOI: 10.1016/j.phrs.2020.104792
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating and rapidly progressing neurodegenerative disorder with no effective disease-modifying treatment up to date. The underlying molecular mechanisms of ALS are not yet completely understood. However, the critical role… read more here.
Keywords: amyotrophic lateral; pre clinical; molecular mechanisms; sclerosis als ... See more keywords
The double sides of hope: The meaning of hope among amyotrophic lateral sclerosis (ALS) patients
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DOI: 10.1080/07481187.2019.1626946
Abstract: Abstract Hope is an important factor in coping and adjusting to life-threatening disease. In this study, we examined the meaning of hope among people with amyotrophic lateral sclerosis (ALS). Semi-structured interviews with 12 people revealed… read more here.
Keywords: amyotrophic lateral; meaning hope; sclerosis als; hope among ... See more keywords
Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)
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DOI: 10.1080/14728222.2020.1738390
Abstract: ABSTRACT Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disorder that targets upper and lower motor neurons and leads to fatal muscle paralysis. Mutations in the superoxide dismutase 1 (SOD1) gene are… read more here.
Keywords: sod1; lateral sclerosis; dismutase sod1; amyotrophic lateral ... See more keywords
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2083958
Abstract: ABSTRACT Introduction Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that lacks an effective treatment. Aggregates of the TAR DNA-binding protein-43 (TDP-43) are observed in 97% of all ALS cases, thus making this protein… read more here.
Keywords: therapeutic target; tdp; lateral sclerosis; sclerosis als ... See more keywords
Advance care planning in amyotrophic lateral sclerosis (ALS): study protocol for a qualitative longitudinal study with persons with ALS and their family carers
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DOI: 10.1136/bmjopen-2021-060451
Abstract: Introduction Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron degenerative disease that has rapid progression and is associated with cognitive impairment. For people with ALS (pALS) and their family carers, advance care planning (ACP)… read more here.
Keywords: family; family carers; lateral sclerosis; qualitative longitudinal ... See more keywords
Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01849-7
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease affecting the neuromuscular system. While there have been a number of important genetic discoveries, there are no therapeutics capable of stopping its insidious progression. Lessons from… read more here.
Keywords: genetics; disease; amyotrophic lateral; sclerosis als ... See more keywords
Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis
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DOI: 10.1371/journal.pone.0182638
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disorder in which only a small proportion of patients carry an identifiable causative genetic lesion. Despite high heritability estimates, a genetic etiology for most sporadic ALS… read more here.
Keywords: amyotrophic lateral; sclerosis als; lateral sclerosis; disease pathogenesis ... See more keywords