The skeletal cell‐derived molecule sclerostin drives bone marrow adipogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25976
Abstract: The bone marrow niche is a dynamic and complex microenvironment that can both regulate, and be regulated by the bone matrix. Within the bone marrow (BM), mesenchymal stromal cell (MSC) precursors reside in a multi‐potent… read more here.
Keywords: sclerostin; adipogenesis; bone; cell ... See more keywords
Serum Sclerostin and Bone Morphogenetic Protein-2 Levels in Patients with Ankylosing Spondylitis: A Meta-Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Calcified Tissue International"
DOI: 10.1007/s00223-019-00542-z
Abstract: Various studies have investigated the serum sclerostin and bone morphogenetic protein-2 (BMP-2) levels in patients with ankylosing spondylitis (AS), but the results were inconsistent. The aim of this meta-analysis was to synthetically assess the associations… read more here.
Keywords: levels patients; ankylosing spondylitis; sclerostin; analysis ... See more keywords
Sclerostin stimulates angiogenesis in human endothelial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.03.001
Abstract: Sclerostin, negative regulator of bone formation, has been originally known as an osteocyte product. Recently, it has been also detected in hypertrophic chondrocytes, distinctive cells of avascular cartilage which is invaded by capillaries and then… read more here.
Keywords: human endothelial; sclerostin; angiogenesis human; sclerostin stimulates ... See more keywords
Sclerostin and its association with insulin resistance in children and adolescents.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2018.07.021
Abstract: INTRODUCTION Recent studies have shown that sclerostin, which is mainly known as a negative regulator of bone formation, could play an important role in the crosstalk between bone and glucose metabolism. The aim of this… read more here.
Keywords: insulin; sclerostin; correlation; bone ... See more keywords
Targeted inhibition of sclerostin for post-menopausal osteoporosis therapy: A critical assessment of the mechanism of action.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2018.02.028
Abstract: Promising news in the treatment of osteoporosis is that sequestering sclerostin from circulation with antibodies stimulates robust bone formation. Pre-clinical studies on rodents and monkeys have confirmed that treatment with anti-sclerostin monoclonal antibody (Scl-Ab) increases… read more here.
Keywords: post menopausal; sclerostin; bone; mechanism action ... See more keywords
Baicalin Nanocomplexes with an In Situ-Forming Biomimetic Gel Implant for Repair of Calvarial Bone Defects via Localized Sclerostin Inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20946
Abstract: In situ-forming hydrogels are highly effective in covering complex and irregular tissue defects. Herein, a biomimetic gel implant (CS-GEL) consisting of methacrylated chondroitin sulfate and gelatin is obtained via visible light irradiation, which displays rapid… read more here.
Keywords: bone; situ forming; sclerostin; gel ... See more keywords
Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52224-3
Abstract: Bone quality in diabetic patients is compromised, leading to weaker bones and increased fracture risk. However, the mechanism by which this occurs in diabetic bone remains to be fully elucidated. We hypothesized that elevated glucose… read more here.
Keywords: glucose acts; elevated glucose; sclerostin expression; sclerostin ... See more keywords
P1680MINERAL METABOLISM CHANGES AFTER RENAL TRANSPLANTATION
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p1680
Abstract: Successful renal transplant restores many physiologic abnormalities, including improvement of chronic kidney disease-mineral and bone disorder (CKD-MBD) syndrome, and modifications of bone-related molecules in disease and health can help to understand pathophysiology of this syndrome.… read more here.
Keywords: pth; fgf23; delta; sclerostin ... See more keywords
Sclerostin and chronic kidney disease: the assay impacts what we (thought to) know
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfx282
Abstract: Background Sclerostin, a 22-kDa protein secreted by osteocytes, acts as a potent inhibitor of osteoblast activity. In chronic kidney disease (CKD), sclerostin is a putative driver of the bone-vascular axis. However, large discrepancies between sclerostin… read more here.
Keywords: chronic kidney; sclerostin; dialysis patients; dialysis ... See more keywords
Sclerostin regulation: a promising therapy for periodontitis by modulating alveolar bone
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000764
Abstract: Abstract Periodontitis is one of the most prevalent epidemics affecting human health and life recently, and exploration of the pathogenesis and treatment of periodontitis has been valued by scholars. In recent years, sclerostin, a new… read more here.
Keywords: sclerostin; regulation; treatment; alveolar bone ... See more keywords
OP0309 Intestinal sclerostin/serotonin axis is modulated by dysbiosis and regulates ilc3 expansion in as patients
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.3995
Abstract: Background Sclerostin is an osteocyte-specific factor that binds to low-density lipoprotein receptor-related protein 5 (LRP5) inhibiting the Wnt signaling pathway and possibly contributing to the pathogenesis of Ankylosing spondylitis (AS). Subclinical gut inflammation observed in… read more here.
Keywords: gdnf; sclerostin serotonin; sclerostin; serotonin ... See more keywords