Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts
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DOI: 10.1002/jbmr.3175
Abstract: Bone formation is coupled to bone resorption throughout life. However, the coupling mechanisms are not fully elucidated. Using Tnfrsf11b‐deficient (OPG–/–) mice, in which bone formation is clearly coupled to bone resorption, we found here that… read more here.
Keywords: sclerostin expression; bone formation; bone; expression ... See more keywords
Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes
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DOI: 10.1038/s41598-019-52224-3
Abstract: Bone quality in diabetic patients is compromised, leading to weaker bones and increased fracture risk. However, the mechanism by which this occurs in diabetic bone remains to be fully elucidated. We hypothesized that elevated glucose… read more here.
Keywords: glucose acts; elevated glucose; sclerostin expression; sclerostin ... See more keywords