Regional distribution of cytochrome c oxidase activity and copper in sclerotic hippocampi of epilepsy patients
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DOI: 10.1002/brb3.1986
Abstract: Disruption of copper homeostasis and dysfunction of mitochondria have been documented in sclerotic hippocampi (HS) of patients with mesial temporal lobe epilepsy (mTLE). However, a potential link between these pathological changes has not been tackled… read more here.
Keywords: epilepsy; cytochrome oxidase; copper; regional distribution ... See more keywords
NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi
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DOI: 10.1016/j.brainres.2020.147230
Abstract: Inflammation plays a role in the pathophysiology of mesial temporal lobe epilepsy (MTLE). Inflammasome pathways, including the NLRP1 and NLRP3-induced ones, promote neuroinflammation and pyroptosis through interleukin (IL)-1β and caspase-1 action. Evaluation of NLRP1 in… read more here.
Keywords: lobe epilepsy; caspase; mesial temporal; hippocampi ... See more keywords