Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114166
Abstract: Hepatocellular carcinoma is one of the most common primary hepatic malignancy. Herein, a series of semisynthesized derivatives (2-30) of the natural product (+)-sclerotiorin (1) was prepared and evaluated the cytotoxic activities against six cancer cell… read more here.
Keywords: hepatocellular carcinoma; sclerotiorin; biological evaluation; semisynthesis biological ... See more keywords
Sclerotiorin stabilizes the assembly of non-fibrillar Abeta42 oligomers with low toxicity, seeding activity and beta-sheet content.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.033
Abstract: The self-assembly of the 42-residue amyloid-β peptide, Aβ42, into fibrillar aggregates is associated with neuronal dysfunction and toxicity in Alzheimer's disease (AD) patient brains, suggesting that small molecules acting on this process might interfere with… read more here.
Keywords: sheet content; low toxicity; seeding activity; sheet ... See more keywords