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Published in 2019 at "Epilepsy Currents"
DOI: 10.1177/1535759718822038
Abstract: Selective Nav1.1 Activation Rescues Dravet Syndrome Mice From Seizures and Premature Death Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi…
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Keywords:
epilepsy;
epileptic encephalopathy;
mice;
dravet syndrome ... See more keywords
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Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221112801
Abstract: Corticohippocampal Circuit Dysfunction in a Mouse Model of Dravet Syndrome Mattis J, Somarowthu A, Goff KM, et al. ELife. 2022;11:e69293. doi:10.7554/eLife.69293. Dravet syndrome (DS) is a neurodevelopmental disorder due to pathogenic variants in SCN1A encoding…
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Keywords:
model dravet;
scn1a mice;
pathology;
dentate gyrus ... See more keywords
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Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280842
Abstract: A purified preparation of cannabidiol (CBD), a cannabis constituent, has been approved for the treatment of intractable childhood epilepsies such as Dravet syndrome. Extensive pharmacological characterization of CBD shows activity at numerous molecular targets but…
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Keywords:
seizure;
scn1a mice;
deletion;
gpr55 ... See more keywords
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Published in 2019 at "eLife"
DOI: 10.7554/elife.46846
Abstract: Dravet Syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic loss of function variants in the gene SCN1A which encodes the voltage gated sodium (Na+) channel subunit Nav1.1. GABAergic interneurons expressing parvalbumin (PV-INs) and…
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Keywords:
vip ins;
scn1a mice;
dravet syndrome;
vasoactive intestinal ... See more keywords