Articles with "scn1a mice" as a keyword



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Dravet Syndrome: A Developmental and Epileptic Encephalopathy

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Published in 2019 at "Epilepsy Currents"

DOI: 10.1177/1535759718822038

Abstract: Selective Nav1.1 Activation Rescues Dravet Syndrome Mice From Seizures and Premature Death Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi… read more here.

Keywords: epilepsy; epileptic encephalopathy; mice; dravet syndrome ... See more keywords
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Blame it on the Inputs: Overexcited Entorhinal Inputs Drive Dentate Gyrus Hyperexcitability in a Mouse Model of Dravet Syndrome

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Published in 2022 at "Epilepsy Currents"

DOI: 10.1177/15357597221112801

Abstract: Corticohippocampal Circuit Dysfunction in a Mouse Model of Dravet Syndrome Mattis J, Somarowthu A, Goff KM, et al. ELife. 2022;11:e69293. doi:10.7554/eLife.69293. Dravet syndrome (DS) is a neurodevelopmental disorder due to pathogenic variants in SCN1A encoding… read more here.

Keywords: model dravet; scn1a mice; pathology; dentate gyrus ... See more keywords
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Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome

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Published in 2023 at "PLOS ONE"

DOI: 10.1371/journal.pone.0280842

Abstract: A purified preparation of cannabidiol (CBD), a cannabis constituent, has been approved for the treatment of intractable childhood epilepsies such as Dravet syndrome. Extensive pharmacological characterization of CBD shows activity at numerous molecular targets but… read more here.

Keywords: seizure; scn1a mice; deletion; gpr55 ... See more keywords
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Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

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Published in 2019 at "eLife"

DOI: 10.7554/elife.46846

Abstract: Dravet Syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic loss of function variants in the gene SCN1A which encodes the voltage gated sodium (Na+) channel subunit Nav1.1. GABAergic interneurons expressing parvalbumin (PV-INs) and… read more here.

Keywords: vip ins; scn1a mice; dravet syndrome; vasoactive intestinal ... See more keywords