Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors
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DOI: 10.1172/jci.insight.150698
Abstract: SCN2A, encoding the neuronal voltage-gated Na+ channel NaV1.2, is one of the most commonly affected loci linked to autism spectrum disorders (ASDs). Most ASD-associated mutations in SCN2A are loss-of-function mutations, but studies examining how such… read more here.
Keywords: voltage gated; scn2a; scn2a 1898; synaptic input ... See more keywords