Abstract Mo054: Long Noncoding RNA LINC00667 Downregulation Leads to SCN5A Alternative Splicing and Arrhythmogenesis
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DOI: 10.1161/res.135.suppl_1.mo054
Abstract: Background: The voltage-gated sodium channel SCN5A, which encodes the Nav1.5 protein, is integral to the propagation of electrical signals in cardiac tissue. SCN5A expression is diminished in cardiomyopathy, significantly increasing the susceptibility to arrhythmias. This… read more here.
Keywords: alternative splicing; mrna; linc00667; scn5a mrna ... See more keywords