Genetic Variants in the SCN9A Gene are Detected in a Minority of Erythromelalgia Patients
Sign Up to like & getrecommendations! Published in 2025 at "Acta Dermato-Venereologica"
DOI: 10.2340/actadv.v105.42022
Abstract: Gain-of-function variants in the voltage-gated sodium channel Nav1.7, encoded by the SCN9A gene, have previously been identified in patients with erythromelalgia, a clinical diagnosis defined by intermittent attacks of painful, hot, swollen, and red skin,… read more here.
Keywords: erythromelalgia; variants scn9a; primary erythromelalgia; scn9a gene ... See more keywords
Effects of SCN9A gene modification on Na+ channel and the expression of nerve growth factor in a rat model of diarrhea‑predominant irritable bowel syndrome.
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DOI: 10.3892/mmr.2017.8061
Abstract: The aim of the present study was to identify whether the sodium voltage-gated channel alpha subunit 9 (SCN9A) gene modification is a potential treatment for diarrhea‑predominant irritable bowel syndrome (D‑IBS), via regulating the Na+ channel and… read more here.
Keywords: scn9a gene; gene modification; expression; gene ... See more keywords