LONG‐TERM EFFICACY AND SAFETY OF LENALIDOMIDE MAINTENANCE IN PATIENTS WITH RELAPSED DIFFUSE LARGE B‐CELL LYMPHOMA WHO ARE NOT ELIGIBLE FOR AUTOLOGOUS TRANSPLANTATION (ASCT)
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DOI: 10.1002/hon.65_2630
Abstract: Introduction: Secondary central nervous system involvement of lymphoma (SCNSL) is a rare ( read more here.
Keywords: cns involvement; scnsl; therapy; cell ... See more keywords
Abstract 4675: Radiation therapy utilization and outcomes in primary and secondary central nervous system lymphoma
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DOI: 10.1158/1538-7445.am2025-4675
Abstract: Radiotherapy (RT) is an established consolidation strategy for primary CNS lymphoma (PCNSL). However, the role of RT in secondary CNSL (SCNSL) is unclear. Here, we describe RT doses, disease failure patterns, and survival outcomes in… read more here.
Keywords: radiation; pcnsl scnsl; cns; scnsl ... See more keywords
Real-world outcomes with CAR T-cell therapy for secondary central nervous system lymphoma are similar between patients with active versus historical involvement
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DOI: 10.1182/blood-2025-1936
Abstract: Background: Secondary central nervous system large B-cell lymphoma (sCNSL) carriers a poor prognosis and is often refractory to standard chemoimmunotherapy. Autologous anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy has revolutionised the treatment of relapsed and/or… read more here.
Keywords: therapy; tisa cel; scnsl; car ... See more keywords
Reduced-dose whole brain radiotherapy is an effective consolidation strategy for parenchymal-only secondary cns lymphoma
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DOI: 10.1182/blood-2025-7181
Abstract: Introduction: While optimal consolidation strategies for patients with secondary central nervous system lymphoma (SCNSL) remain debated, autologous stem cell transplant (ASCT) is commonly used in eligible patients. However, effective alternatives are needed for those who… read more here.
Keywords: brain; brain radiotherapy; consolidation; scnsl ... See more keywords
De novo secondary central nervous system lymphoma: A real-world cohort study over two decades
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DOI: 10.1182/blood-2025-8085
Abstract: Secondary central nervous system lymphoma (SCNSL) involves CNS spread of systemic lymphoma, occurring at diagnosis (de novo) or at relapse. While SCNSL is associated with more aggressive disease and poorer prognosis, de novo presentation often… read more here.
Keywords: central nervous; nervous system; cns targeting; scnsl ... See more keywords