Muscarinic and N‐methyl‐D‐aspartate receptor blockade reveal differences in hippocampal local field potentials in mice with low cholinergic tone
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23462
Abstract: We hypothesize that hippocampal local field potentials in acetylcholine (ACh)‐deficient mutant mice, compared to wild‐type (WT) mice, will show lower sensitivity to muscarinic cholinergic antagonist scopolamine (5 mg/kg i.p.) but higher sensitivity to NMDA receptor antagonist… read more here.
Keywords: theta; power; scopolamine; gamma ... See more keywords
Inhibition of scopolamine‐induced memory and mitochondrial impairment by betanin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23076
Abstract: Mitochondrial dysfunction and oxidative stress are identified to contribute to the mechanisms responsible for the pathogenesis of Alzheimer's disease (AD). Scopolamine (SCO) as a potent drug for inducing memory and learning impairment is associated with… read more here.
Keywords: scopolamine; induced memory; impairment betanin; betanin ... See more keywords
Neuroprotective effects of 20(S)‐protopanaxatriol (PPT) on scopolamine‐induced cognitive deficits in mice
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.6044
Abstract: 20(S)‐protopanaxatriol (PPT), one of the ginsenosides from Panax ginseng, has been reported to have neuroprotective effects and to improve memory. The present study was designed to investigate the protective effect of PPT on scopolamine‐induced cognitive… read more here.
Keywords: scopolamine; neuroprotective effects; protopanaxatriol ppt; induced cognitive ... See more keywords
Neuroprotective effects of total alkaloids fraction of Huperzia serrata on scopolamine‐induced neurodegenerative animals
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7602
Abstract: Huperzia serrata contains Huperzine A (HupA)—an alkaloid used to treat cognitive dysfunction. In this study, we used the total alkaloids (HsAE) to investigate their potential in managing cognitive impairment in comparison with HupA. The antioxidant… read more here.
Keywords: huperzia serrata; total alkaloids; scopolamine; scopolamine induced ... See more keywords
Effect of intravenous scopolamine before stapling, on postoperative nausea and vomiting in sleeve gastrectomy patients: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Surgical Endoscopy"
DOI: 10.1007/s00464-022-09075-3
Abstract: Postoperative nausea and vomiting (PONV) is a common complication of general anesthesia that is further potentiated in an obese patient undergoing a bariatric procedure. Literature shows trials of myriad of drugs used alone or in… read more here.
Keywords: intravenous scopolamine; trial; scopolamine; sleeve gastrectomy ... See more keywords
Neuroprotection of SAK3 on scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "Cytotechnology"
DOI: 10.1007/s10616-019-00366-7
Abstract: Alzheimer’s disease (AD) is the most common type of senile dementia. A number of factors have been proposed regarding pathology of AD, such as presence of β-amyloid, and cholinergic and oxidative stress. SAK3 (ethyl 8′-methyl-2′,5-dioxo-2-piperidin-1-ylspiro[cyclopentene-3,3′-imidazo[1,2-a]pyridine]-1-carboxylate)… read more here.
Keywords: scopolamine; human neuroblastoma; neuroblastoma sy5y; scopolamine induced ... See more keywords
Attempt of scopolamine-facilitated robbery: an original case of poisoning by inhalation confirmed by LC–MS/MS and review of the literature
Sign Up to like & getrecommendations! Published in 2019 at "Forensic Toxicology"
DOI: 10.1007/s11419-019-00492-z
Abstract: Purpose Scopolamine, an alkaloid found in certain plants, has become a drug of use for recreational and predatory purposes. We present here the case of an attempted scopolamine-facilitated robbery, via inhalation, with full recovery of… read more here.
Keywords: scopolamine; scopolamine facilitated; case; inhalation ... See more keywords
Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer’s Disease Model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01426-5
Abstract: Alzheimer’s disease (AD) is one of the most complicated neurodegenerative diseases, and several hypotheses have been associated with its development and progression, such as those involving glucose hypometabolism, the cholinergic system, calcium imbalance, inflammation, oxidative… read more here.
Keywords: scopolamine; administration; alzheimer disease; model ... See more keywords
Cortico-Hippocampal Memory Enhancing Activity of Hesperetin on Scopolamine-Induced Amnesia in Mice: Role of Antioxidant Defense Systems, Cholinergic Neurotransmission and Expression of BDNF
Sign Up to like & getrecommendations! Published in 2019 at "IBRO Reports"
DOI: 10.1016/j.ibror.2019.09.051
Abstract: Alzheimer disease (AD) is an age related neurodegenerative disease causing severe cognitive and memory decline in elderly people. Flavonoids play neuroprotective role by inhibiting and/or modifying the self-assembly of the amyloid-β (Aβ) or tau peptide… read more here.
Keywords: scopolamine; scopolamine induced; role; antioxidant defense ... See more keywords
Protective effects of SGB121, ginsenoside F1-enriched ginseng extract, on scopolamine-induced cytotoxicity and memory impairments
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.104165
Abstract: Abstract Ginsenosides have been reported to improve memory impairments. However, the effects of metabolized minor ginsenosides on neuronal damage and cognitive function remain unclear. We investigated the effects of SGB121, ginsenoside F1 enriched ginseng extract,… read more here.
Keywords: scopolamine; effects sgb121; scopolamine induced; sgb121 ginsenoside ... See more keywords
Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135993
Abstract: Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior… read more here.
Keywords: scopolamine; anxiety; differences shape; sex differences ... See more keywords