Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.04.015
Abstract: The present study evaluated the effect of the change in the orientation of the VH-VL variable domains to VL-VH on the physicochemical and functional properties of two scorpion toxin-neutralizing scFvs. The results showed that the… read more here.
Keywords: assessment orientations; toxin neutralizing; scorpion toxin; comparative assessment ... See more keywords
BotAF, a new Buthus occitanus tunetanus scorpion toxin, produces potent analgesia in rodents
Sign Up to like & getrecommendations! Published in 2018 at "Toxicon"
DOI: 10.1016/j.toxicon.2018.01.003
Abstract: &NA; This work reports the purification of new potent scorpion neuropeptide, named BotAF, by an activity‐guided screening approach. BotAF is a 64‐residue long‐chain peptide that shares very high similarity with the original &bgr;‐like scorpion toxin… read more here.
Keywords: scorpion; anti nociceptive; botaf; activity ... See more keywords