Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Cell Chemical Biology"
DOI: 10.1016/j.chembiol.2021.04.020
Abstract: The COVID-19 pandemic has been disastrous to society and effective drugs are urgent needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention.… read more here.
Keywords: development potent; potent selective; like protease; papain like ... See more keywords
Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.947272
Abstract: The newly emerged severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) can result in dysregulated interferon (IFN) responses that contribute to disease severity. The papain-like protease of SARS-CoV-2 (SCoV2-PLpro) has been previously reported to attenuate IFN… read more here.
Keywords: deubiquitination; rlr signaling; papain like; sars cov ... See more keywords