Single-molecule analysis of phospholipid scrambling by TMEM16F
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1717956115
Abstract: Significance Membrane proteins that translocate various compounds across biological membranes play important roles in maintaining intracellular homeostasis in cells. Scramblases are membrane proteins that translocate phospholipids between the inner and outer leaflets of the plasma… read more here.
Keywords: molecule; single molecule; scramblase; phospholipid scrambling ... See more keywords
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
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DOI: 10.7554/elife.44364
Abstract: Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca2+-dependent lipid scramblase, its regulation mechanism has remained… read more here.
Keywords: stepwise activation; scramblase; activation mechanism; mechanism ... See more keywords
Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F
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DOI: 10.7554/elife.44365
Abstract: The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which encompasses calcium-activated channels for ions and lipids. Here, we… read more here.
Keywords: scramblase tmem16f; lipid scramblase; scramblase; cryo structures ... See more keywords