Membrane structure‐responsive lipid scramblase activity of the TMEM63/OSCA family
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DOI: 10.1002/1873-3468.15084
Abstract: Phospholipids are asymmetrically distributed in the plasma membrane (PM), and scramblases disrupt this asymmetry by shuffling phospholipids. We recently identified mouse Tmem63b as a membrane structure‐responsive scramblase. Tmem63b belongs to the TMEM63/OSCA family of ion… read more here.
Keywords: membrane structure; scramblase; structure responsive; scramblase activity ... See more keywords
Structure and function of the human apoptotic scramblase Xkr4
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DOI: 10.1038/s41467-025-62739-1
Abstract: Phosphatidylserine externalization on the surface of dying cells is a key signal for their recognition and clearance by macrophages and is mediated by members of the X-Kell related (Xkr) protein family. Defective Xkr-mediated scrambling impairs… read more here.
Keywords: function human; structure function; xkr4; apoptotic scramblase ... See more keywords
Activation of TMEM16E scramblase induces ligand independent growth factor receptor signaling and macropinocytosis for membrane repair
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DOI: 10.1038/s42003-025-07465-6
Abstract: The calcium-dependent phospholipid scramblase TMEM16E mediates ion transport and lipid translocation across the plasma membrane. TMEM16E also contributes to protection of membrane structure by facilitating cellular repair signaling. Our research reveals that TMEM16E activation promotes… read more here.
Keywords: tmem16e; scramblase; growth factor; membrane ... See more keywords
Single-molecule analysis of phospholipid scrambling by TMEM16F
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1717956115
Abstract: Significance Membrane proteins that translocate various compounds across biological membranes play important roles in maintaining intracellular homeostasis in cells. Scramblases are membrane proteins that translocate phospholipids between the inner and outer leaflets of the plasma… read more here.
Keywords: molecule; single molecule; scramblase; phospholipid scrambling ... See more keywords
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
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DOI: 10.7554/elife.44364
Abstract: Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca2+-dependent lipid scramblase, its regulation mechanism has remained… read more here.
Keywords: stepwise activation; scramblase; activation mechanism; mechanism ... See more keywords
Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F
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DOI: 10.7554/elife.44365
Abstract: The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which encompasses calcium-activated channels for ions and lipids. Here, we… read more here.
Keywords: scramblase tmem16f; lipid scramblase; scramblase; cryo structures ... See more keywords