Erratum to: Zebrafish phenotypic screen identifies novel Notch antagonists
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0437-0
Abstract: The authors would like to note that in the original online first version of this article, the symbol ɣ is missing from the text where ɣ-secretase is stated. Also, labels to figures in the Results… read more here.
Keywords: zebrafish phenotypic; phenotypic screen; identifies novel; screen identifies ... See more keywords
Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.02.010
Abstract: Summary Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell (ESC)-like state by expression of single reprogramming factor. We used CRISPR activation to perform a genome-scale, reprogramming screen in EpiSCs… read more here.
Keywords: genome scale; crispra screen; screen identifies; scale crispra ... See more keywords
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity
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DOI: 10.1038/s41388-020-01592-6
Abstract: Cancer cell expression of PD-L1 leads to T cells exhaustion by transducing co-inhibitory signal, and further understanding the regulation of PD-L1 in cancer cells may provide additional therapeutic strategies. Here by drug repurposing screen, we… read more here.
Keywords: degradation; identifies amlodipine; screen identifies; repurposing screen ... See more keywords
Screen identifies fasudil as a radioprotector on human fibroblasts.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac042
Abstract: Background Radioprotectors safeguard biological system exposed to ionizing radiation (IR) by protecting normal cells from radiation damage during radiotherapy. Due to the toxicity and limited clinical utility of the present radioprotectors, it prompts us to… read more here.
Keywords: identifies fasudil; radioprotector; human fibroblasts; screen identifies ... See more keywords
A Microenvironment Screen Identifies Compounds Targeting pre-LSCs.
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DOI: 10.1158/2159-8290.cd-rw2016-212
Abstract: 2-ME2 selectively targets pre-LSCs by inhibiting MYC translation and SCL activity. read more here.
Keywords: screen identifies; identifies compounds; microenvironment screen; compounds targeting ... See more keywords